Literature DB >> 2431704

Salivary concentrations of pirmenol as a possible cause of unpleasant taste.

B F Johnson, V Shekar, T Woodman, A T Canada.   

Abstract

Salivary concentrations of the anti-arrhythmic, pirmenol, were compared with plasma concentrations in six patients. Group mean salivary values tended to be higher despite high plasma protein binding, suggesting the possibility of an active transport process. The observed salivary concentrations are reasonably close to those detectable in healthy volunteers as tasting unpleasant.

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Year:  1986        PMID： 2431704      PMCID： PMC1401175          DOI： 10.1111/j.1365-2125.1986.tb02944.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  8 in total

1.  pH-dependent secretion of procainamide into saliva.

Authors:  J R Koup; W J Jusko; A L Goldfarb
Journal:  J Pharm Sci       Date:  1975-12       Impact factor: 3.534

2.  Estimation of pharmacokinetic parameters of lithium from saliva and urine.

Authors:  U Groth; W Prellwitz; E Jähnchen
Journal:  Clin Pharmacol Ther       Date:  1974-09       Impact factor: 6.875

3.  The excretion of drugs in saliva. Antibiotics.

Authors:  J F Borzelleca; H M Cherrick
Journal:  J Oral Ther Pharmacol       Date:  1965-11

4.  Disposition of intravenous pirmenol.

Authors:  S W Sanders; J M Nappi; R L Foltz; J R Lutz; J L Anderson
Journal:  J Clin Pharmacol       Date:  1983 Feb-Mar       Impact factor: 3.126

5.  Comparison of plasma and saliva levels of metoprolol and oxprenolol.

Authors:  C P Dawes; M J Kendall; V A John
Journal:  Br J Clin Pharmacol       Date:  1978-03       Impact factor: 4.335

6.  Effects of pirmenol HCl on electrophysiologic properties of cardiac Purkinje fibers.

Authors:  R F Reder; P Danilo; M R Rosen
Journal:  Eur J Pharmacol       Date:  1980-02       Impact factor: 4.432

7.  Pirmenol, a new antiarrhythmic agent: initial study of efficacy, safety and pharmacokinetics.

Authors:  S C Hammill; D G Shand; P A Routledge; M C Hindman; J T Baker; E L Pritchett
Journal:  Circulation       Date:  1982-02       Impact factor: 29.690

8.  CL-845 (pirmenol hydrochloride): a new orally effective long-acting antiarrhythmic agent.

Authors:  T J Steffe; T E Mertz; S G Hastings; R E Potoczak; H R Kaplan
Journal:  J Pharmacol Exp Ther       Date:  1980-07       Impact factor: 4.030
  8 in total
  1 in total

1.  Time-dependent variability of chloroquine secretion into human saliva.

Authors:  C O Onyeji; F A Ogunbona
Journal:  Pharm World Sci       Date:  1996-12
  1 in total

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