Literature DB >> 24316784

Is genetic testing of value in predicting and treating obesity?

Maggie C Y Ng1, Donald W Bowden.   

Abstract

Obesity is a multifactorial disease resulting from the interaction between genetic factors and lifestyle. Identification of rare genetic variations with strong effects on obesity has been useful in diagnosing and designing personalized therapy for early-onset or syndromic obesity. However, common variants identified in recent genome-wide association studies have limited clinical value.

Entities:  

Mesh：

Year:  2013        PMID： 24316784      PMCID： PMC4073883     

Source DB:  PubMed          Journal:  N C Med J        ISSN： 0029-2559


  30 in total

1.  A haplotype map of the human genome.

Authors: 
Journal:  Nature       Date:  2005-10-27       Impact factor: 49.962

2.  Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

Authors:  Lucia A Hindorff; Praveen Sethupathy; Heather A Junkins; Erin M Ramos; Jayashri P Mehta; Francis S Collins; Teri A Manolio
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-27       Impact factor: 11.205

3.  Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene.

Authors:  Karani S Vimaleswaran; Shengxu Li; Jing Hua Zhao; Jian'an Luan; Sheila A Bingham; Kay-Tee Khaw; Ulf Ekelund; Nicholas J Wareham; Ruth J F Loos
Journal:  Am J Clin Nutr       Date:  2009-06-24       Impact factor: 7.045

4.  Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.

Authors:  Ewan Birney; John A Stamatoyannopoulos; Anindya Dutta; Roderic Guigó; Thomas R Gingeras; Elliott H Margulies; Zhiping Weng; Michael Snyder; Emmanouil T Dermitzakis; Robert E Thurman; Michael S Kuehn; Christopher M Taylor; Shane Neph; Christoph M Koch; Saurabh Asthana; Ankit Malhotra; Ivan Adzhubei; Jason A Greenbaum; Robert M Andrews; Paul Flicek; Patrick J Boyle; Hua Cao; Nigel P Carter; Gayle K Clelland; Sean Davis; Nathan Day; Pawandeep Dhami; Shane C Dillon; Michael O Dorschner; Heike Fiegler; Paul G Giresi; Jeff Goldy; Michael Hawrylycz; Andrew Haydock; Richard Humbert; Keith D James; Brett E Johnson; Ericka M Johnson; Tristan T Frum; Elizabeth R Rosenzweig; Neerja Karnani; Kirsten Lee; Gregory C Lefebvre; Patrick A Navas; Fidencio Neri; Stephen C J Parker; Peter J Sabo; Richard Sandstrom; Anthony Shafer; David Vetrie; Molly Weaver; Sarah Wilcox; Man Yu; Francis S Collins; Job Dekker; Jason D Lieb; Thomas D Tullius; Gregory E Crawford; Shamil Sunyaev; William S Noble; Ian Dunham; France Denoeud; Alexandre Reymond; Philipp Kapranov; Joel Rozowsky; Deyou Zheng; Robert Castelo; Adam Frankish; Jennifer Harrow; Srinka Ghosh; Albin Sandelin; Ivo L Hofacker; Robert Baertsch; Damian Keefe; Sujit Dike; Jill Cheng; Heather A Hirsch; Edward A Sekinger; Julien Lagarde; Josep F Abril; Atif Shahab; Christoph Flamm; Claudia Fried; Jörg Hackermüller; Jana Hertel; Manja Lindemeyer; Kristin Missal; Andrea Tanzer; Stefan Washietl; Jan Korbel; Olof Emanuelsson; Jakob S Pedersen; Nancy Holroyd; Ruth Taylor; David Swarbreck; Nicholas Matthews; Mark C Dickson; Daryl J Thomas; Matthew T Weirauch; James Gilbert; Jorg Drenkow; Ian Bell; XiaoDong Zhao; K G Srinivasan; Wing-Kin Sung; Hong Sain Ooi; Kuo Ping Chiu; Sylvain Foissac; Tyler Alioto; Michael Brent; Lior Pachter; Michael L Tress; Alfonso Valencia; Siew Woh Choo; Chiou Yu Choo; Catherine Ucla; Caroline Manzano; Carine Wyss; Evelyn Cheung; Taane G Clark; James B Brown; Madhavan Ganesh; Sandeep Patel; Hari Tammana; Jacqueline Chrast; Charlotte N Henrichsen; Chikatoshi Kai; Jun Kawai; Ugrappa Nagalakshmi; Jiaqian Wu; Zheng Lian; Jin Lian; Peter Newburger; Xueqing Zhang; Peter Bickel; John S Mattick; Piero Carninci; Yoshihide Hayashizaki; Sherman Weissman; Tim Hubbard; Richard M Myers; Jane Rogers; Peter F Stadler; Todd M Lowe; Chia-Lin Wei; Yijun Ruan; Kevin Struhl; Mark Gerstein; Stylianos E Antonarakis; Yutao Fu; Eric D Green; Ulaş Karaöz; Adam Siepel; James Taylor; Laura A Liefer; Kris A Wetterstrand; Peter J Good; Elise A Feingold; Mark S Guyer; Gregory M Cooper; George Asimenos; Colin N Dewey; Minmei Hou; Sergey Nikolaev; Juan I Montoya-Burgos; Ari Löytynoja; Simon Whelan; Fabio Pardi; Tim Massingham; Haiyan Huang; Nancy R Zhang; Ian Holmes; James C Mullikin; Abel Ureta-Vidal; Benedict Paten; Michael Seringhaus; Deanna Church; Kate Rosenbloom; W James Kent; Eric A Stone; Serafim Batzoglou; Nick Goldman; Ross C Hardison; David Haussler; Webb Miller; Arend Sidow; Nathan D Trinklein; Zhengdong D Zhang; Leah Barrera; Rhona Stuart; David C King; Adam Ameur; Stefan Enroth; Mark C Bieda; Jonghwan Kim; Akshay A Bhinge; Nan Jiang; Jun Liu; Fei Yao; Vinsensius B Vega; Charlie W H Lee; Patrick Ng; Atif Shahab; Annie Yang; Zarmik Moqtaderi; Zhou Zhu; Xiaoqin Xu; Sharon Squazzo; Matthew J Oberley; David Inman; Michael A Singer; Todd A Richmond; Kyle J Munn; Alvaro Rada-Iglesias; Ola Wallerman; Jan Komorowski; Joanna C Fowler; Phillippe Couttet; Alexander W Bruce; Oliver M Dovey; Peter D Ellis; Cordelia F Langford; David A Nix; Ghia Euskirchen; Stephen Hartman; Alexander E Urban; Peter Kraus; Sara Van Calcar; Nate Heintzman; Tae Hoon Kim; Kun Wang; Chunxu Qu; Gary Hon; Rosa Luna; Christopher K Glass; M Geoff Rosenfeld; Shelley Force Aldred; Sara J Cooper; Anason Halees; Jane M Lin; Hennady P Shulha; Xiaoling Zhang; Mousheng Xu; Jaafar N S Haidar; Yong Yu; Yijun Ruan; Vishwanath R Iyer; Roland D Green; Claes Wadelius; Peggy J Farnham; Bing Ren; Rachel A Harte; Angie S Hinrichs; Heather Trumbower; Hiram Clawson; Jennifer Hillman-Jackson; Ann S Zweig; Kayla Smith; Archana Thakkapallayil; Galt Barber; Robert M Kuhn; Donna Karolchik; Lluis Armengol; Christine P Bird; Paul I W de Bakker; Andrew D Kern; Nuria Lopez-Bigas; Joel D Martin; Barbara E Stranger; Abigail Woodroffe; Eugene Davydov; Antigone Dimas; Eduardo Eyras; Ingileif B Hallgrímsdóttir; Julian Huppert; Michael C Zody; Gonçalo R Abecasis; Xavier Estivill; Gerard G Bouffard; Xiaobin Guan; Nancy F Hansen; Jacquelyn R Idol; Valerie V B Maduro; Baishali Maskeri; Jennifer C McDowell; Morgan Park; Pamela J Thomas; Alice C Young; Robert W Blakesley; Donna M Muzny; Erica Sodergren; David A Wheeler; Kim C Worley; Huaiyang Jiang; George M Weinstock; Richard A Gibbs; Tina Graves; Robert Fulton; Elaine R Mardis; Richard K Wilson; Michele Clamp; James Cuff; Sante Gnerre; David B Jaffe; Jean L Chang; Kerstin Lindblad-Toh; Eric S Lander; Maxim Koriabine; Mikhail Nefedov; Kazutoyo Osoegawa; Yuko Yoshinaga; Baoli Zhu; Pieter J de Jong
Journal:  Nature       Date:  2007-06-14       Impact factor: 49.962

5.  A second generation human haplotype map of over 3.1 million SNPs.

Authors:  Kelly A Frazer; Dennis G Ballinger; David R Cox; David A Hinds; Laura L Stuve; Richard A Gibbs; John W Belmont; Andrew Boudreau; Paul Hardenbol; Suzanne M Leal; Shiran Pasternak; David A Wheeler; Thomas D Willis; Fuli Yu; Huanming Yang; Changqing Zeng; Yang Gao; Haoran Hu; Weitao Hu; Chaohua Li; Wei Lin; Siqi Liu; Hao Pan; Xiaoli Tang; Jian Wang; Wei Wang; Jun Yu; Bo Zhang; Qingrun Zhang; Hongbin Zhao; Hui Zhao; Jun Zhou; Stacey B Gabriel; Rachel Barry; Brendan Blumenstiel; Amy Camargo; Matthew Defelice; Maura Faggart; Mary Goyette; Supriya Gupta; Jamie Moore; Huy Nguyen; Robert C Onofrio; Melissa Parkin; Jessica Roy; Erich Stahl; Ellen Winchester; Liuda Ziaugra; David Altshuler; Yan Shen; Zhijian Yao; Wei Huang; Xun Chu; Yungang He; Li Jin; Yangfan Liu; Yayun Shen; Weiwei Sun; Haifeng Wang; Yi Wang; Ying Wang; Xiaoyan Xiong; Liang Xu; Mary M Y Waye; Stephen K W Tsui; Hong Xue; J Tze-Fei Wong; Luana M Galver; Jian-Bing Fan; Kevin Gunderson; Sarah S Murray; Arnold R Oliphant; Mark S Chee; Alexandre Montpetit; Fanny Chagnon; Vincent Ferretti; Martin Leboeuf; Jean-François Olivier; Michael S Phillips; Stéphanie Roumy; Clémentine Sallée; Andrei Verner; Thomas J Hudson; Pui-Yan Kwok; Dongmei Cai; Daniel C Koboldt; Raymond D Miller; Ludmila Pawlikowska; Patricia Taillon-Miller; Ming Xiao; Lap-Chee Tsui; William Mak; You Qiang Song; Paul K H Tam; Yusuke Nakamura; Takahisa Kawaguchi; Takuya Kitamoto; Takashi Morizono; Atsushi Nagashima; Yozo Ohnishi; Akihiro Sekine; Toshihiro Tanaka; Tatsuhiko Tsunoda; Panos Deloukas; Christine P Bird; Marcos Delgado; Emmanouil T Dermitzakis; Rhian Gwilliam; Sarah Hunt; Jonathan Morrison; Don Powell; Barbara E Stranger; Pamela Whittaker; David R Bentley; Mark J Daly; Paul I W de Bakker; Jeff Barrett; Yves R Chretien; Julian Maller; Steve McCarroll; Nick Patterson; Itsik Pe'er; Alkes Price; Shaun Purcell; Daniel J Richter; Pardis Sabeti; Richa Saxena; Stephen F Schaffner; Pak C Sham; Patrick Varilly; David Altshuler; Lincoln D Stein; Lalitha Krishnan; Albert Vernon Smith; Marcela K Tello-Ruiz; Gudmundur A Thorisson; Aravinda Chakravarti; Peter E Chen; David J Cutler; Carl S Kashuk; Shin Lin; Gonçalo R Abecasis; Weihua Guan; Yun Li; Heather M Munro; Zhaohui Steve Qin; Daryl J Thomas; Gilean McVean; Adam Auton; Leonardo Bottolo; Niall Cardin; Susana Eyheramendy; Colin Freeman; Jonathan Marchini; Simon Myers; Chris Spencer; Matthew Stephens; Peter Donnelly; Lon R Cardon; Geraldine Clarke; David M Evans; Andrew P Morris; Bruce S Weir; Tatsuhiko Tsunoda; James C Mullikin; Stephen T Sherry; Michael Feolo; Andrew Skol; Houcan Zhang; Changqing Zeng; Hui Zhao; Ichiro Matsuda; Yoshimitsu Fukushima; Darryl R Macer; Eiko Suda; Charles N Rotimi; Clement A Adebamowo; Ike Ajayi; Toyin Aniagwu; Patricia A Marshall; Chibuzor Nkwodimmah; Charmaine D M Royal; Mark F Leppert; Missy Dixon; Andy Peiffer; Renzong Qiu; Alastair Kent; Kazuto Kato; Norio Niikawa; Isaac F Adewole; Bartha M Knoppers; Morris W Foster; Ellen Wright Clayton; Jessica Watkin; Richard A Gibbs; John W Belmont; Donna Muzny; Lynne Nazareth; Erica Sodergren; George M Weinstock; David A Wheeler; Imtaz Yakub; Stacey B Gabriel; Robert C Onofrio; Daniel J Richter; Liuda Ziaugra; Bruce W Birren; Mark J Daly; David Altshuler; Richard K Wilson; Lucinda L Fulton; Jane Rogers; John Burton; Nigel P Carter; Christopher M Clee; Mark Griffiths; Matthew C Jones; Kirsten McLay; Robert W Plumb; Mark T Ross; Sarah K Sims; David L Willey; Zhu Chen; Hua Han; Le Kang; Martin Godbout; John C Wallenburg; Paul L'Archevêque; Guy Bellemare; Koji Saeki; Hongguang Wang; Daochang An; Hongbo Fu; Qing Li; Zhen Wang; Renwu Wang; Arthur L Holden; Lisa D Brooks; Jean E McEwen; Mark S Guyer; Vivian Ota Wang; Jane L Peterson; Michael Shi; Jack Spiegel; Lawrence M Sung; Lynn F Zacharia; Francis S Collins; Karen Kennedy; Ruth Jamieson; John Stewart
Journal:  Nature       Date:  2007-10-18       Impact factor: 49.962

6.  FTO genotype and the weight loss benefits of moderate intensity exercise.

Authors:  Jonathan A Mitchell; Timothy S Church; Tuomo Rankinen; Conrad P Earnest; Xuemei Sui; Steven N Blair
Journal:  Obesity (Silver Spring)       Date:  2009-10-01       Impact factor: 5.002

Review 7.  Obesity genomics: assessing the transferability of susceptibility loci across diverse populations.

Authors:  Yingchang Lu; Ruth Jf Loos
Journal:  Genome Med       Date:  2013-06-28       Impact factor: 11.117

8.  An integrated map of genetic variation from 1,092 human genomes.

Authors:  Goncalo R Abecasis; Adam Auton; Lisa D Brooks; Mark A DePristo; Richard M Durbin; Robert E Handsaker; Hyun Min Kang; Gabor T Marth; Gil A McVean
Journal:  Nature       Date:  2012-11-01       Impact factor: 49.962

9.  A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

Authors:  Keri L Monda; Gary K Chen; Kira C Taylor; Cameron Palmer; Todd L Edwards; Leslie A Lange; Maggie C Y Ng; Adebowale A Adeyemo; Matthew A Allison; Lawrence F Bielak; Guanjie Chen; Mariaelisa Graff; Marguerite R Irvin; Suhn K Rhie; Guo Li; Yongmei Liu; Youfang Liu; Yingchang Lu; Michael A Nalls; Yan V Sun; Mary K Wojczynski; Lisa R Yanek; Melinda C Aldrich; Adeyinka Ademola; Christopher I Amos; Elisa V Bandera; Cathryn H Bock; Angela Britton; Ulrich Broeckel; Quiyin Cai; Neil E Caporaso; Chris S Carlson; John Carpten; Graham Casey; Wei-Min Chen; Fang Chen; Yii-Der I Chen; Charleston W K Chiang; Gerhard A Coetzee; Ellen Demerath; Sandra L Deming-Halverson; Ryan W Driver; Patricia Dubbert; Mary F Feitosa; Ye Feng; Barry I Freedman; Elizabeth M Gillanders; Omri Gottesman; Xiuqing Guo; Talin Haritunians; Tamara Harris; Curtis C Harris; Anselm J M Hennis; Dena G Hernandez; Lorna H McNeill; Timothy D Howard; Barbara V Howard; Virginia J Howard; Karen C Johnson; Sun J Kang; Brendan J Keating; Suzanne Kolb; Lewis H Kuller; Abdullah Kutlar; Carl D Langefeld; Guillaume Lettre; Kurt Lohman; Vaneet Lotay; Helen Lyon; Joann E Manson; William Maixner; Yan A Meng; Kristine R Monroe; Imran Morhason-Bello; Adam B Murphy; Josyf C Mychaleckyj; Rajiv Nadukuru; Katherine L Nathanson; Uma Nayak; Amidou N'diaye; Barbara Nemesure; Suh-Yuh Wu; M Cristina Leske; Christine Neslund-Dudas; Marian Neuhouser; Sarah Nyante; Heather Ochs-Balcom; Adesola Ogunniyi; Temidayo O Ogundiran; Oladosu Ojengbede; Olufunmilayo I Olopade; Julie R Palmer; Edward A Ruiz-Narvaez; Nicholette D Palmer; Michael F Press; Evandine Rampersaud; Laura J Rasmussen-Torvik; Jorge L Rodriguez-Gil; Babatunde Salako; Eric E Schadt; Ann G Schwartz; Daniel A Shriner; David Siscovick; Shad B Smith; Sylvia Wassertheil-Smoller; Elizabeth K Speliotes; Margaret R Spitz; Lara Sucheston; Herman Taylor; Bamidele O Tayo; Margaret A Tucker; David J Van Den Berg; Digna R Velez Edwards; Zhaoming Wang; John K Wiencke; Thomas W Winkler; John S Witte; Margaret Wrensch; Xifeng Wu; James J Yang; Albert M Levin; Taylor R Young; Neil A Zakai; Mary Cushman; Krista A Zanetti; Jing Hua Zhao; Wei Zhao; Yonglan Zheng; Jie Zhou; Regina G Ziegler; Joseph M Zmuda; Jyotika K Fernandes; Gary S Gilkeson; Diane L Kamen; Kelly J Hunt; Ida J Spruill; Christine B Ambrosone; Stefan Ambs; Donna K Arnett; Larry Atwood; Diane M Becker; Sonja I Berndt; Leslie Bernstein; William J Blot; Ingrid B Borecki; Erwin P Bottinger; Donald W Bowden; Gregory Burke; Stephen J Chanock; Richard S Cooper; Jingzhong Ding; David Duggan; Michele K Evans; Caroline Fox; W Timothy Garvey; Jonathan P Bradfield; Hakon Hakonarson; Struan F A Grant; Ann Hsing; Lisa Chu; Jennifer J Hu; Dezheng Huo; Sue A Ingles; Esther M John; Joanne M Jordan; Edmond K Kabagambe; Sharon L R Kardia; Rick A Kittles; Phyllis J Goodman; Eric A Klein; Laurence N Kolonel; Loic Le Marchand; Simin Liu; Barbara McKnight; Robert C Millikan; Thomas H Mosley; Badri Padhukasahasram; L Keoki Williams; Sanjay R Patel; Ulrike Peters; Curtis A Pettaway; Patricia A Peyser; Bruce M Psaty; Susan Redline; Charles N Rotimi; Benjamin A Rybicki; Michèle M Sale; Pamela J Schreiner; Lisa B Signorello; Andrew B Singleton; Janet L Stanford; Sara S Strom; Michael J Thun; Mara Vitolins; Wei Zheng; Jason H Moore; Scott M Williams; Shamika Ketkar; Xiaofeng Zhu; Alan B Zonderman; Charles Kooperberg; George J Papanicolaou; Brian E Henderson; Alex P Reiner; Joel N Hirschhorn; Ruth J F Loos; Kari E North; Christopher A Haiman
Journal:  Nat Genet       Date:  2013-04-14       Impact factor: 38.330

Review 10.  The genetics of human obesity.

Authors:  Qianghua Xia; Struan F A Grant
Journal:  Ann N Y Acad Sci       Date:  2013-01-29       Impact factor: 5.691
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  3 in total

Review 1.  CRISPR/Cas9, the Powerful New Genome-Editing Tool for Putative Therapeutics in Obesity.

Authors:  María José Franco-Tormo; Mireille Salas-Crisostomo; Nuno Barbosa Rocha; Henning Budde; Sérgio Machado; Eric Murillo-Rodríguez
Journal:  J Mol Neurosci       Date:  2018-05-07       Impact factor: 3.444

Review 2.  Screening for hormonal, monogenic, and syndromic disorders in obese infants and children.

Authors:  Kelly Mason; Laura Page; Pinar Gumus Balikcioglu
Journal:  Pediatr Ann       Date:  2014-09       Impact factor: 1.132

Review 3.  Obesity subtypes, related biomarkers & heterogeneity.

Authors:  Laura Perez-Campos Mayoral; Gabriel Mayoral Andrade; Eduardo Perez-Campos Mayoral; Teresa Hernandez Huerta; Socorro Pina Canseco; Francisco J Rodal Canales; Héctor Alejandro Cabrera-Fuentes; Margarito Martinez Cruz; Alma Dolores Pérez Santiago; Juan José Alpuche; Edgar Zenteno; Hector Martínez Ruíz; Ruth Martínez Cruz; Julia Hernandez Jeronimo; Eduardo Perez-Campos
Journal:  Indian J Med Res       Date:  2020-01       Impact factor: 2.375
  3 in total

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