Jessica H Spahn1, Wenjun Li, Daniel Kreisel. 1. aDepartment of Surgery bDepartment of Pathology & Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.
Abstract
PURPOSE OF REVIEW: To examine the recent literature on the role of innate cells in immunity to transplanted tissue. It specifically addresses the impact of monocytes/macrophages, neutrophils, natural killer cells, and platelets. RECENT FINDINGS: Current research indicates that innate immunity plays a dual role in response to transplanted tissue with the ability to either facilitate rejection or promote tolerance. Intriguingly, some of these cells are even capable of reacting to allogeneic cells, a feature usually only attributed to cells of the adaptive immune system. SUMMARY: This review highlights the new therapeutic targets in the innate immune system that may be useful in the treatment of transplant recipients. It also emphasizes the need to use caution in exploring these new therapeutics.
PURPOSE OF REVIEW: To examine the recent literature on the role of innate cells in immunity to transplanted tissue. It specifically addresses the impact of monocytes/macrophages, neutrophils, natural killer cells, and platelets. RECENT FINDINGS: Current research indicates that innate immunity plays a dual role in response to transplanted tissue with the ability to either facilitate rejection or promote tolerance. Intriguingly, some of these cells are even capable of reacting to allogeneic cells, a feature usually only attributed to cells of the adaptive immune system. SUMMARY: This review highlights the new therapeutic targets in the innate immune system that may be useful in the treatment of transplant recipients. It also emphasizes the need to use caution in exploring these new therapeutics.
Authors: Shuichiro Uehara; Catharine M Chase; William H Kitchens; Harris S Rose; Robert B Colvin; Paul S Russell; Joren C Madsen Journal: J Immunol Date: 2005-09-01 Impact factor: 5.422
Authors: Benjamin J Kopecky; Christian Frye; Yuriko Terada; Keki R Balsara; Daniel Kreisel; Kory J Lavine Journal: Am J Transplant Date: 2020-01-29 Impact factor: 8.086
Authors: I Kourtzelis; A Ferreira; I Mitroulis; D Ricklin; S R Bornstein; C Waskow; J D Lambris; T Chavakis Journal: Horm Metab Res Date: 2014-10-28 Impact factor: 2.936
Authors: Mayuko Uehara; Zhabiz Solhjou; Naima Banouni; Vivek Kasinath; Ye Xiaqun; Li Dai; Osman Yilmam; Mine Yilmaz; Takaharu Ichimura; Paolo Fiorina; Paulo N Martins; Shunsuke Ohori; Indira Guleria; Omar H Maarouf; Stefan G Tullius; Martina M McGrath; Reza Abdi Journal: Sci Rep Date: 2018-02-06 Impact factor: 4.379