| Literature DB >> 24316668 |
Shinya Sogame1, Yoshihito Suenaga1, Masakazu Atobe2, Masashi Kawanishi1, Eiichi Tanaka1, Shiro Miyoshi1.
Abstract
We describe a medicinal chemistry approach to generate a series of benzimidazoles bearing thiazolidin-4-one using scaffold hopping from thiazole 1, our previously described thiazole. Our goal was to discover a potent and permeable small-molecule ADAMTS-5 inhibitor. The results suggest that small compound 22 shows promise as a potent small-molecule ADAMTS-5 inhibitor with good permeability.Entities:
Keywords: ADAMTS-5; Benzimidazole; Inhibitor; Osteoarthritis; Thiazolidin-4-one
Mesh：
Substances：
Year: 2013 PMID： 24316668 DOI： 10.1016/j.ejmech.2013.10.075
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514