Elham Emami1, Marla Kabawat2, Pierre H Rompre3, Jocelyne S Feine4. 1. Département de Dentisterie et de Restauration, Faculté de Médecine Dentaire, Université de Montréal, Montreal, Canada. Electronic address: elham.emami@umontreal.ca. 2. Département de Dentisterie et de Restauration, Faculté de Médecine Dentaire, Université de Montréal, Montreal, Canada. 3. Département de Stomatologie, Faculté de Médecine Dentaire, Université de Montréal, Montreal, Canada. 4. Oral Health and Society Research Unit, Faculty of Dentistry; Department of Epidemiology and Biostatistics and Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Abstract
OBJECTIVES: The aim of this meta-analysis was to compare the efficacy of antifungal therapy with any other alternative methods used for the treatment of denture stomatitis. DATA SOURCES: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews were searched, complemented by hand searching, until the first week of January 2013. STUDY SELECTION: Included studies consisted of randomized clinical trials published in English or French, which compared antifungals with any other alternative or placebo, used for the treatment of denture stomatitis. The remission of clinical signs of denture stomatitis, and the reduction in Candida colony counts were considered as the clinical and microbiological outcomes, respectively. Random effects models were used to conduct the statistical analyses. RESULTS: From 233 identified articles, a total of 15 manuscripts on 14 randomized controlled trials were included in systematic review and 8 in the meta-analysis. No statistically significant difference between antifungal treatment and disinfection methods was found for both clinical (OR=0.7; 95% CI: 0.32-1.36; Z=-1.14; p=0.256) and microbiological (OR=0.8; 95% CI: 0.26-2.5; Z=-0.35; p=0.724) outcomes. The meta-analysis showed a statistically significant difference between an antifungal and a placebo for the microbiological outcome (OR=0.32; 95% CI: 0.12-0.89; Z=-2.2; p=0.028), favouring the antifungals. However, there was no statistically significant difference between antifungal and placebo for the clinical outcome (OR=0.2; 95% CI: 0.04-1.04; Z=-1.9; p=0.056). CONCLUSIONS: Disinfection agents, antiseptic mouthwashes, natural substances with antimicrobial properties, microwave disinfection and photodynamic therapy could be suggested as an adjunct or alternative to antifungal medications in the treatment of denture stomatitis.
OBJECTIVES: The aim of this meta-analysis was to compare the efficacy of antifungal therapy with any other alternative methods used for the treatment of denture stomatitis. DATA SOURCES: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews were searched, complemented by hand searching, until the first week of January 2013. STUDY SELECTION: Included studies consisted of randomized clinical trials published in English or French, which compared antifungals with any other alternative or placebo, used for the treatment of denture stomatitis. The remission of clinical signs of denture stomatitis, and the reduction in Candida colony counts were considered as the clinical and microbiological outcomes, respectively. Random effects models were used to conduct the statistical analyses. RESULTS: From 233 identified articles, a total of 15 manuscripts on 14 randomized controlled trials were included in systematic review and 8 in the meta-analysis. No statistically significant difference between antifungal treatment and disinfection methods was found for both clinical (OR=0.7; 95% CI: 0.32-1.36; Z=-1.14; p=0.256) and microbiological (OR=0.8; 95% CI: 0.26-2.5; Z=-0.35; p=0.724) outcomes. The meta-analysis showed a statistically significant difference between an antifungal and a placebo for the microbiological outcome (OR=0.32; 95% CI: 0.12-0.89; Z=-2.2; p=0.028), favouring the antifungals. However, there was no statistically significant difference between antifungal and placebo for the clinical outcome (OR=0.2; 95% CI: 0.04-1.04; Z=-1.9; p=0.056). CONCLUSIONS: Disinfection agents, antiseptic mouthwashes, natural substances with antimicrobial properties, microwave disinfection and photodynamic therapy could be suggested as an adjunct or alternative to antifungal medications in the treatment of denture stomatitis.
Authors: Julyana de Araújo Oliveira; Ingrid Carla Guedes da Silva; Leonardo Antunes Trindade; Edeltrudes Oliveira Lima; Hugo Lemes Carlo; Alessandro Leite Cavalcanti; Ricardo Dias de Castro Journal: Evid Based Complement Alternat Med Date: 2014-12-09 Impact factor: 2.629
Authors: Raphael F de Souza; Muhammad Faheem Khiyani; Carolina A L Chaves; Jocelyne Feine; Jean Barbeau; Ramón Fuentes; Eduardo Borie; Luciana C Crizostomo; Claudia H Silva-Lovato; Pierre Rompre; Elham Emami Journal: Trials Date: 2017-05-05 Impact factor: 2.279
Authors: Thamer A Almangour; Keith S Kaye; Mohammed Alessa; Khalid Eljaaly; Fadilah Sfouq Aleanizy; Aynaa Alsharidi; Fahad M Al Majid; Naif H Alotaibi; Abdullah A Alzeer; Faris S Alnezary; Abdullah A Alhifany Journal: Saudi Pharm J Date: 2021-03-24 Impact factor: 4.330