Ergin Arslan1, Tutkun Talih2, Bahadir Oz3, Bülent Halaclar4, Kasim Caglayan5, Mesut Sipahi5. 1. Bozok University, Faculty of Medicine, Department of Surgery, Yozgat, Turkey. Electronic address: ergnrsln@hotmail.com. 2. Kayseri Training and Education Hospital, Department of Surgery, Kayseri, Turkey. 3. Erciyes University, Faculty of Medicine, Department of Surgery, Kayseri, Turkey. 4. Aksaray State Hospital, Department of Surgery, Aksaray, Turkey. 5. Bozok University, Faculty of Medicine, Department of Surgery, Yozgat, Turkey.
Abstract
OBJECTIVES: The aim of this experimental study was to compare the effectiveness and reliability of lovastatin and hyaluronic acid + carboxymethyl cellulose (Seprafilm). MATERIALS AND METHODS: Thirty two female Wistar-Albino rats weighing between 250 and 300 g were used in the study. The rats were divided into four groups as sham, control, lovastatin and Seprafilm each of which contained 8 rats. All rats were sacrificed on the 14th day after surgery. Macroscopic adhesion, microscopic adhesion and tPA, MDA and NO values were evaluated. RESULTS: Macroscopic adhesion formation was significantly lower in the sham and study groups than in the control group (p < 0.05). Microscopic classification adhesion formation was significantly lower in the sham and study groups than in the control group (p < 0.05), and the tPA, MDA and NO values showed statistically significant differences among the groups. CONCLUSION: Lovastatin and Seprafilm were equally effective in preventing postoperative intra abdominal adhesions. The study groups were showed significant superiority to the control group.
OBJECTIVES: The aim of this experimental study was to compare the effectiveness and reliability of lovastatin and hyaluronic acid + carboxymethyl cellulose (Seprafilm). MATERIALS AND METHODS: Thirty two female Wistar-Albino rats weighing between 250 and 300 g were used in the study. The rats were divided into four groups as sham, control, lovastatin and Seprafilm each of which contained 8 rats. All rats were sacrificed on the 14th day after surgery. Macroscopic adhesion, microscopic adhesion and tPA, MDA and NO values were evaluated. RESULTS: Macroscopic adhesion formation was significantly lower in the sham and study groups than in the control group (p < 0.05). Microscopic classification adhesion formation was significantly lower in the sham and study groups than in the control group (p < 0.05), and the tPA, MDA and NO values showed statistically significant differences among the groups. CONCLUSION:Lovastatin and Seprafilm were equally effective in preventing postoperative intra abdominal adhesions. The study groups were showed significant superiority to the control group.
Authors: Ji Pang; Pengcheng Jiang; Ying Wang; Lu Jiang; Hai Qian; Yan Tao; Ruxia Shi; Jizong Gao; Yongchang Chen; Yan Wu Journal: J Ovarian Res Date: 2018-03-06 Impact factor: 4.234