| Literature DB >> 24316127 |
Jianzheng Fang1, Shangqian Wang1, Hainan Wang1, Shengli Zhang1, Shifeng Su1, Zhen Song1, Yunfei Deng1, Jian Qian1, Jinbao Gu1, Bianjiang Liu1, Jingyi Cao2, Zengjun Wang3.
Abstract
Studies of the relationship between male infertility and CYP1A1 polymorphisms are inconclusive. To drive a more precise estimation, we performed a meta-analysis based on 1060 cases and 1225 controls from 7 published case-control studies. PubMed and CNKI literature search were conducted to identify all eligible studies investigating such a relationship. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the additive model, dominant model, recessive model, and allele-frequency genetic model. In the overall analysis, the frequency of CYP1A12A genotype was significantly associated with susceptibility to idiopathic male infertility. Further stratified analysis by ethnicity showed notable association between the polymorphism and the risk of idiopathic male infertility in Asians. In conclusion, these results support that the CYP1A1 2A genotype polymorphism mainly contributes to idiopathic male infertility susceptibility in Asians but not in Caucasians.Entities:
Keywords: CI; CYP1A1; CYP1A1 male infertility; Cytochrome P4501A1; Meta-analysis; OR; Polymorphism; SNPs; confidence interval; odds ratio; single-nucleotide polymorphisms
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Year: 2013 PMID： 24316127 DOI： 10.1016/j.gene.2013.11.011
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688