Literature DB >> 24315366

Proteostasis impairment: at the intersection between Alzheimer's disease and diabetes.

Danilo B Medinas1, Claudio Hetz.   

Abstract

Altered insulin signaling and neuroinflammation are emerging features of Alzheimer's disease. Lourenco et al. (2013) identify a pathogenic mechanism that is shared between Alzheimer's disease and diabetes and contributes to memory loss through a common molecular event: the control of protein synthesis by PKR and the downstream phosphorylation of eIF2α.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID: 24315366     DOI: 10.1016/j.cmet.2013.11.009

Source DB:  PubMed          Journal:  Cell Metab        ISSN: 1550-4131            Impact factor:   27.287


  4 in total

1.  Terminal Galactosylation and Sialylation Switching on Membrane Glycoproteins upon TNF-Alpha-Induced Insulin Resistance in Adipocytes.

Authors:  Benjamin L Parker; Morten Thaysen-Andersen; Daniel J Fazakerley; Mira Holliday; Nicolle H Packer; David E James
Journal:  Mol Cell Proteomics       Date:  2015-11-04       Impact factor: 5.911

2.  Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress.

Authors:  Andrea D'Osualdo; Veronica G Anania; Kebing Yu; Jennie R Lill; Randal J Kaufman; Shu-ichi Matsuzawa; John C Reed
Journal:  PLoS One       Date:  2015-06-18       Impact factor: 3.240

Review 3.  Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease.

Authors:  Fernanda G De Felice; Mychael V Lourenco
Journal:  Front Aging Neurosci       Date:  2015-05-19       Impact factor: 5.750

4.  PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model.

Authors:  F Mouton-Liger; A-S Rebillat; S Gourmaud; C Paquet; A Leguen; J Dumurgier; P Bernadelli; V Taupin; L Pradier; T Rooney; J Hugon
Journal:  Cell Death Dis       Date:  2015-01-15       Impact factor: 8.469

  4 in total

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