Elena Garcia-Martin1, Jose M Larrosa2, Vicente Polo2, Maria Satue2, Marcia L Marques3, Raquel Alarcia4, Maria Seral4, Isabel Fuertes2, Sofia Otin2, Luis E Pablo2. 1. Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain; Aragones Institute of Health Sciences, Zaragoza, Spain. Electronic address: egmvivax@yahoo.com. 2. Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain; Aragones Institute of Health Sciences, Zaragoza, Spain. 3. Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain; Aragones Institute of Health Sciences, Zaragoza, Spain; Instituto de Moléstias Oculares, São Paulo, Brasil. 4. Neurology Department, Miguel Servet University Hospital, Zaragoza, Spain.
Abstract
PURPOSE: To evaluate the thickness of the 10 retinal layers in the paramacular area of Parkinson disease patients using a new segmentation technology of optical coherence tomography (OCT) to examine whether the thickness of specific layers predicts neurodegeneration or Parkinson disease severity. DESIGN: Observational prospective study. METHODS: Parkinson disease patients (n = 129) and age-matched healthy subjects (n = 129) were enrolled. The Spectralis OCT system was used to automatically segment all retinal layers in a parafoveal scan using the new segmentation application prototype. Mean thickness of each layer was calculated and compared between Parkinson disease patients and healthy subjects, and between Parkinson disease patients with disease durations of less than or at least 10 years. A correlation analysis was performed to evaluate the association between retinal layer thickness, duration of disease, and Parkinson disease severity. Logistic regression analysis was performed to determine the most sensitive layer for predicting axonal atrophy. RESULTS: Parkinson disease patients showed statistically significant reduced thickness in the retinal nerve fiber, ganglion cell, inner plexiform, and outer plexiform layers and increased thickness in the inner nuclear layer compared with healthy subjects (P < .05). The inner retinal layers were more affected in Parkinson disease patients with long disease duration. The ganglion cell layer thickness was inversely correlated with disease duration and Parkinson disease severity, and was predictive of axonal damage in Parkinson disease patients. CONCLUSIONS: The segmentation application of the Spectralis OCT revealed retinal layer atrophy in Parkinson disease patients, especially in the inner layers of patients with long disease duration. Ganglion cell layer reduction was associated with increased axonal damage.
PURPOSE: To evaluate the thickness of the 10 retinal layers in the paramacular area of Parkinson diseasepatients using a new segmentation technology of optical coherence tomography (OCT) to examine whether the thickness of specific layers predicts neurodegeneration or Parkinson disease severity. DESIGN: Observational prospective study. METHODS:Parkinson diseasepatients (n = 129) and age-matched healthy subjects (n = 129) were enrolled. The Spectralis OCT system was used to automatically segment all retinal layers in a parafoveal scan using the new segmentation application prototype. Mean thickness of each layer was calculated and compared between Parkinson diseasepatients and healthy subjects, and between Parkinson diseasepatients with disease durations of less than or at least 10 years. A correlation analysis was performed to evaluate the association between retinal layer thickness, duration of disease, and Parkinson disease severity. Logistic regression analysis was performed to determine the most sensitive layer for predicting axonal atrophy. RESULTS:Parkinson diseasepatients showed statistically significant reduced thickness in the retinal nerve fiber, ganglion cell, inner plexiform, and outer plexiform layers and increased thickness in the inner nuclear layer compared with healthy subjects (P < .05). The inner retinal layers were more affected in Parkinson diseasepatients with long disease duration. The ganglion cell layer thickness was inversely correlated with disease duration and Parkinson disease severity, and was predictive of axonal damage in Parkinson diseasepatients. CONCLUSIONS: The segmentation application of the Spectralis OCT revealed retinal layer atrophy in Parkinson diseasepatients, especially in the inner layers of patients with long disease duration. Ganglion cell layer reduction was associated with increased axonal damage.
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