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Literature DB >> 24315092

snRNA catalysts in the spliceosome's ancient core.

Abstract

The spliceosome, an assembly of snRNAs and proteins, catalyzes the removal of introns from premessenger RNAs. A new study identifies specific phosphates in the U2-U6 snRNA complex that position two catalytic metals. Remarkably, these correspond precisely to metal-binding phosphates in a homologous structure of Group II self-splicing introns, long proposed to be the ribozyme progenitor of spliceosome.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2013 PMID： 24315092 PMCID： PMC4162089 DOI： 10.1016/j.cell.2013.11.022

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

11 in total

1. A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome.

Authors: H D Madhani; C Guthrie
Journal: Cell Date: 1992-11-27 Impact factor: 41.582

2. RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.

Authors: Maria Anokhina; Sergey Bessonov; Zhichao Miao; Eric Westhof; Klaus Hartmuth; Reinhard Lührmann
Journal: EMBO J Date: 2013-09-03 Impact factor: 11.598

Review 3. Dynamic RNA-RNA interactions in the spliceosome.

Authors: H D Madhani; C Guthrie
Journal: Annu Rev Genet Date: 1994 Impact factor: 16.830

4. Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing.

Authors: M J Moore; P A Sharp
Journal: Nature Date: 1993-09-23 Impact factor: 49.962

5. A general two-metal-ion mechanism for catalytic RNA.

Authors: T A Steitz; J A Steitz
Journal: Proc Natl Acad Sci U S A Date: 1993-07-15 Impact factor: 11.205

Review 6. Identification of catalytic metal ion ligands in ribozymes.

Authors: John K Frederiksen; Joseph A Piccirilli
Journal: Methods Date: 2009-08-03 Impact factor: 3.608

7. U6 snRNA function in nuclear pre-mRNA splicing: a phosphorothioate interference analysis of the U6 phosphate backbone.

Authors: Y T Yu; P A Maroney; E Darzynkiwicz; T W Nilsen
Journal: RNA Date: 1995-03 Impact factor: 4.942

snRNA catalysts in the spliceosome's ancient core.

1. A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome.

2. RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.

Review 3. Dynamic RNA-RNA interactions in the spliceosome.

4. Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing.

5. A general two-metal-ion mechanism for catalytic RNA.

Review 6. Identification of catalytic metal ion ligands in ribozymes.

7. U6 snRNA function in nuclear pre-mRNA splicing: a phosphorothioate interference analysis of the U6 phosphate backbone.

8. Visualizing group II intron catalysis through the stages of splicing.

9. Crystal structure of Prp8 reveals active site cavity of the spliceosome.

10. RNA catalyses nuclear pre-mRNA splicing.

Review 1. The Conservation and Function of RNA Secondary Structure in Plants.

2. RNA structure drives interaction with proteins.

Review 3. Structure, Regulation, and Function of Linear and Circular Long Non-Coding RNAs.