Woo Jin Lee1, Hye Rim Moon1, Chong Hyun Won1, Sung Eun Chang1, Jee Ho Choi1, Kee Chan Moon1, Mi Woo Lee2. 1. Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 2. Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Electronic address: jijulee@hanmail.net.
Abstract
BACKGROUND: Lymphoblastic lymphoma (LBL) is a rare neoplasm of precursor lymphocytes, and cutaneous involvement is present in less than 20% of cases. OBJECTIVE: We sought to describe the clinical and histopathological features of cutaneous LBL. METHODS: We retrospectively examined the clinical and histologic features of 13 patients with cutaneous LBL, 6 with B-LBL and 7 with T-LBL. RESULTS: Five of 6 patients with B-LBL had lesions in the head and neck area, whereas 4 of 7 patients with T-LBL developed skin lesions on sites other than the head and neck. Seven patients (1 case of B-LBL, and 6 of 7 cases of T-LBL) developed multiple skin lesions, and the T-LBL cases frequently developed multiple skin lesions in the head, neck, and throughout the torso. Complete remission was achieved in 9 patients (3 patients with T-LBL and all patients with B-LBL). LIMITATIONS: This study used a retrospective design and included a small sample size. CONCLUSION: This study compared the clinical features of T-LBL and B-LBL, in particular the affected sites and number of skin lesions. Cutaneous T-LBL is likely to be accompanied by disseminated disease and has a relatively poor prognosis compared with B-LBL.
BACKGROUND:Lymphoblastic lymphoma (LBL) is a rare neoplasm of precursor lymphocytes, and cutaneous involvement is present in less than 20% of cases. OBJECTIVE: We sought to describe the clinical and histopathological features of cutaneous LBL. METHODS: We retrospectively examined the clinical and histologic features of 13 patients with cutaneous LBL, 6 with B-LBL and 7 with T-LBL. RESULTS: Five of 6 patients with B-LBL had lesions in the head and neck area, whereas 4 of 7 patients with T-LBL developed skin lesions on sites other than the head and neck. Seven patients (1 case of B-LBL, and 6 of 7 cases of T-LBL) developed multiple skin lesions, and the T-LBL cases frequently developed multiple skin lesions in the head, neck, and throughout the torso. Complete remission was achieved in 9 patients (3 patients with T-LBL and all patients with B-LBL). LIMITATIONS: This study used a retrospective design and included a small sample size. CONCLUSION: This study compared the clinical features of T-LBL and B-LBL, in particular the affected sites and number of skin lesions. Cutaneous T-LBL is likely to be accompanied by disseminated disease and has a relatively poor prognosis compared with B-LBL.