Michael H Dahan1, Mohammed Agdi2, Fady Shehata2, Weonyoung Son2, Seang Lin Tan2. 1. McGill Reproductive Center, McGill University, Royal Victoria Hospital, 687 Pine Ave west, Montreal, QC H3A 1A1, Canada. Electronic address: michael.dahan@muhc.mcgill.ca. 2. McGill Reproductive Center, McGill University, Royal Victoria Hospital, 687 Pine Ave west, Montreal, QC H3A 1A1, Canada.
Abstract
OBJECTIVES: To compare rates of pregnancy and IVF parameters in subjects who were stimulated with FSH plus recombinant human luteinizing hormone or menopausal gonadotropins. To determine whether responses to type of LH differ in poor or good responders. STUDY DESIGN: Retrospective analysis at a university-based fertility center. Subjects were women with good and poor ovarian reserve, who underwent in vitro fertilization during a 2 year period, as part of a long agonist (N=122), or microdose flair (N=79) protocol. Measurements included FSH and LH dose, number of oocytes collected, number of embryos obtained, and pregnancy and clinical pregnancy rates. RESULTS: Patients treated with r-hLH (n=105) had higher numbers of eggs retrieved and of embryos while using less FSH than their hMG-treated (n=96) counterparts. Pregnancy and clinical pregnancy rates were significantly higher with r-hLH than with hMG protocols (p=0.008 and 0.009, respectively). If patients had a baseline serum FSH level ≥10IU/L, clinical pregnancy rates were higher when r-hLH was used. When the antral follicle count was below 6 no significant differences in stimulation parameters or outcomes were detected between the groups. CONCLUSION: r-hLH may be beneficial when compared to hMG and used for in-vitro fertilization, except in subjects with baseline follicle counts less than 6. Further data should be obtained.
OBJECTIVES: To compare rates of pregnancy and IVF parameters in subjects who were stimulated with FSH plus recombinant human luteinizing hormone or menopausal gonadotropins. To determine whether responses to type of LH differ in poor or good responders. STUDY DESIGN: Retrospective analysis at a university-based fertility center. Subjects were women with good and poor ovarian reserve, who underwent in vitro fertilization during a 2 year period, as part of a long agonist (N=122), or microdose flair (N=79) protocol. Measurements included FSH and LH dose, number of oocytes collected, number of embryos obtained, and pregnancy and clinical pregnancy rates. RESULTS:Patients treated with r-hLH (n=105) had higher numbers of eggs retrieved and of embryos while using less FSH than their hMG-treated (n=96) counterparts. Pregnancy and clinical pregnancy rates were significantly higher with r-hLH than with hMG protocols (p=0.008 and 0.009, respectively). If patients had a baseline serum FSH level ≥10IU/L, clinical pregnancy rates were higher when r-hLH was used. When the antral follicle count was below 6 no significant differences in stimulation parameters or outcomes were detected between the groups. CONCLUSION:r-hLH may be beneficial when compared to hMG and used for in-vitro fertilization, except in subjects with baseline follicle counts less than 6. Further data should be obtained.
Authors: Alina M Mahfoudh; Jeong H Moon; Sara Henderson; Elena Garcia-Cerrudo; Weon-Young Son; Michael H Dahan Journal: J Assist Reprod Genet Date: 2017-02-28 Impact factor: 3.412
Authors: Guy Shrem; Mali Salmon-Divon; Alina M Mahfoudh; Jacques Balayla; Alexander Volodarsky-Perel; Sara Henderson; Atif Zeadna; Weon-Young Son; Naama Steiner; Michael H Dahan Journal: Reprod Sci Date: 2021-06-11 Impact factor: 3.060