Literature DB >> 24314672

A novel indigoid anti-tuberculosis agent.

Larry L Klein1, Valentina Petukhova2, Baojie Wan2, Yuehong Wang2, Bernard D Santasiero3, David C Lankin4, Guido F Pauli5, Scott G Franzblau5.   

Abstract

The structure of a novel indigoid component was characterized by X-ray crystallography. This compound exhibited excellent anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv in whole cell culture showing a submicromolar minimum inhibitory concentration (MIC). A synthesis of this molecule was designed and carried out to produce sufficient material for further testing. The in vitro profile, structure, and first synthesis of this indigoid component is reported.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Anti-tuberculosis; Indigoid; X-ray

Mesh：

Substances：

Year:  2013        PMID： 24314672      PMCID： PMC3922930          DOI： 10.1016/j.bmcl.2013.11.024

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

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Journal:  RSC Adv       Date:  2019-12-13       Impact factor: 4.036

2.  Nanoscale isoindigo-carriers: self-assembly and tunable properties.

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