OBJECTIVE: To evaluate the impact of obesity on prostate cancer detection, as measured by the body mass index (BMI) in a Korean biopsy population. PATIENTS AND METHODS: We retrospectively reviewed the records of 1213 men who underwent transrectal ultrasonography-guided prostate biopsy at our institution. Biopsy outcomes were analysed with respect to various variables, including patient age, prostate-specific antigen (PSA), prostate volume, digital rectal examination (DRE) findings and obesity, defined as BMI ≥25 kg/m(2) , an Asian BMI category. RESULTS: Among 1213 men, 408 (33.6%) were obese and 344 (28.4%) had a positive biopsy. Obese men were younger (65.5 vs 67.1 years, P = 0.003), had a larger prostate (49.2 vs 42.9 mL, P < 0.001) and were less likely to have any abnormality on DRE (8.1 vs 15.9% P < 0.001) than non-obese men. In the multivariate analysis, obesity was significantly associated with a higher risk of prostate cancer detection in men undergoing biopsy (odds ratio [OR] = 1.446, P = 0.024). In addition, obesity was significantly associated with a higher rate of biopsy-detected high grade (Gleason score ≥4 + 3) disease, and this association remained after multivariate adjustment (OR = 1.498, P = 0.039). CONCLUSIONS: Obese men were younger, had a larger prostate, and had less tendency to have an abnormality on DRE than non-obese men. Obesity was associated with a higher risk of prostate cancer detection as an independent factor, including high grade prostate cancer in a Korean biopsy population.
OBJECTIVE: To evaluate the impact of obesity on prostate cancer detection, as measured by the body mass index (BMI) in a Korean biopsy population. PATIENTS AND METHODS: We retrospectively reviewed the records of 1213 men who underwent transrectal ultrasonography-guided prostate biopsy at our institution. Biopsy outcomes were analysed with respect to various variables, including patient age, prostate-specific antigen (PSA), prostate volume, digital rectal examination (DRE) findings and obesity, defined as BMI ≥25 kg/m(2) , an Asian BMI category. RESULTS: Among 1213 men, 408 (33.6%) were obese and 344 (28.4%) had a positive biopsy. Obesemen were younger (65.5 vs 67.1 years, P = 0.003), had a larger prostate (49.2 vs 42.9 mL, P < 0.001) and were less likely to have any abnormality on DRE (8.1 vs 15.9% P < 0.001) than non-obesemen. In the multivariate analysis, obesity was significantly associated with a higher risk of prostate cancer detection in men undergoing biopsy (odds ratio [OR] = 1.446, P = 0.024). In addition, obesity was significantly associated with a higher rate of biopsy-detected high grade (Gleason score ≥4 + 3) disease, and this association remained after multivariate adjustment (OR = 1.498, P = 0.039). CONCLUSIONS:Obesemen were younger, had a larger prostate, and had less tendency to have an abnormality on DRE than non-obesemen. Obesity was associated with a higher risk of prostate cancer detection as an independent factor, including high grade prostate cancer in a Korean biopsy population.
Authors: Brandy-Joe Milliron; Michael Bruneau; Elias Obeid; Laura Gross; Lisa Bealin; Christa Smaltz; Veda N Giri Journal: Prostate Date: 2019-03-24 Impact factor: 4.104
Authors: Iván González-Chavarría; Rita P Cerro; Natalie P Parra; Felipe A Sandoval; Felipe A Zuñiga; Valeska A Omazábal; Liliana I Lamperti; Silvana P Jiménez; Edelmira A Fernandez; Nicolas A Gutiérrez; Federico S Rodriguez; Sergio A Onate; Oliberto Sánchez; Juan C Vera; Jorge R Toledo Journal: PLoS One Date: 2014-08-29 Impact factor: 3.240