Literature DB >> 24313755

Nanoparticles strengthen intracellular tension and retard cellular migration.

Chor Yong Tay1, Pingqiang Cai, Magdiel I Setyawati, Wanru Fang, Lay Poh Tan, Catherine H L Hong, Xiaodong Chen, David Tai Leong.   

Abstract

Nanoparticles can have profound effects on cell biology. Here, we show that after TiO2, SiO2, and hydroxyapatite nanoparticles treatment, TR146 epithelial cell sheet displayed slower migration. Cells after exposure to the nanoparticles showed increased cell contractility with significantly impaired wound healing capability however without any apparent cytotoxicity. We showed the mechanism is through nanoparticle-mediated massive disruption of the intracellular microtubule assembly, thereby triggering a positive feedback that promoted stronger substrate adhesions thus leading to limited cell motility.

Entities:  

Mesh：

Year:  2013        PMID： 24313755     DOI： 10.1021/nl4032549

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  48 in total

1.  Quantifying the effects of engineered nanomaterials on endothelial cell architecture and vascular barrier integrity using a cell pair model.

Authors:  Feyisayo Eweje; Herdeline Ann M Ardoña; John F Zimmerman; Blakely B O'Connor; Seungkuk Ahn; Thomas Grevesse; Karla N Rivera; Dimitrios Bitounis; Philip Demokritou; Kevin Kit Parker
Journal:  Nanoscale       Date:  2019-10-03       Impact factor: 7.790

Review 2.  Carbon black and titanium dioxide nanoparticles induce distinct molecular mechanisms of toxicity.

Authors:  Sonja Boland; Salik Hussain; Armelle Baeza-Squiban
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2014-09-30

3.  Nuclear Membrane-Targeted Gold Nanoparticles Inhibit Cancer Cell Migration and Invasion.

Authors:  Moustafa R K Ali; Yue Wu; Deepraj Ghosh; Brian H Do; Kuangcai Chen; Michelle R Dawson; Ning Fang; Todd A Sulchek; Mostafa A El-Sayed
Journal:  ACS Nano       Date:  2017-03-27       Impact factor: 15.881

Review 4.  Diverse Applications of Nanomedicine.

Authors:  Beatriz Pelaz; Christoph Alexiou; Ramon A Alvarez-Puebla; Frauke Alves; Anne M Andrews; Sumaira Ashraf; Lajos P Balogh; Laura Ballerini; Alessandra Bestetti; Cornelia Brendel; Susanna Bosi; Monica Carril; Warren C W Chan; Chunying Chen; Xiaodong Chen; Xiaoyuan Chen; Zhen Cheng; Daxiang Cui; Jianzhong Du; Christian Dullin; Alberto Escudero; Neus Feliu; Mingyuan Gao; Michael George; Yury Gogotsi; Arnold Grünweller; Zhongwei Gu; Naomi J Halas; Norbert Hampp; Roland K Hartmann; Mark C Hersam; Patrick Hunziker; Ji Jian; Xingyu Jiang; Philipp Jungebluth; Pranav Kadhiresan; Kazunori Kataoka; Ali Khademhosseini; Jindřich Kopeček; Nicholas A Kotov; Harald F Krug; Dong Soo Lee; Claus-Michael Lehr; Kam W Leong; Xing-Jie Liang; Mei Ling Lim; Luis M Liz-Marzán; Xiaowei Ma; Paolo Macchiarini; Huan Meng; Helmuth Möhwald; Paul Mulvaney; Andre E Nel; Shuming Nie; Peter Nordlander; Teruo Okano; Jose Oliveira; Tai Hyun Park; Reginald M Penner; Maurizio Prato; Victor Puntes; Vincent M Rotello; Amila Samarakoon; Raymond E Schaak; Youqing Shen; Sebastian Sjöqvist; Andre G Skirtach; Mahmoud G Soliman; Molly M Stevens; Hsing-Wen Sung; Ben Zhong Tang; Rainer Tietze; Buddhisha N Udugama; J Scott VanEpps; Tanja Weil; Paul S Weiss; Itamar Willner; Yuzhou Wu; Lily Yang; Zhao Yue; Qian Zhang; Qiang Zhang; Xian-En Zhang; Yuliang Zhao; Xin Zhou; Wolfgang J Parak
Journal:  ACS Nano       Date:  2017-03-14       Impact factor: 15.881

5.  Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins.

Authors:  Moustafa R K Ali; Yue Wu; Yan Tang; Haopeng Xiao; Kuangcai Chen; Tiegang Han; Ning Fang; Ronghu Wu; Mostafa A El-Sayed
Journal:  Proc Natl Acad Sci U S A       Date:  2017-06-26       Impact factor: 11.205

6.  Silver Nanoparticles Alter Cell Adhesion and Proliferation of Sheep Primary Mesothelial Cells.

Authors:  Zoi V Arsenopoulou; Ioannis A Taitzoglou; Paschalis-Adam Molyvdas; Konstantinos I Gourgoulianis; Chrissi Hatzoglou; Sotirios G Zarogiannis
Journal:  In Vivo       Date:  2018 Jan-Feb       Impact factor: 2.155

7.  Selenite-Releasing Bone Mineral Nanoparticles Retard Bone Tumor Growth and Improve Healthy Tissue Functions In Vivo.

Authors:  Yanhua Wang; Hang Hao; Haoming Liu; Yifan Wang; Yan Li; Gaojie Yang; Jun Ma; Chuanbin Mao; Shengmin Zhang
Journal:  Adv Healthc Mater       Date:  2015-06-23       Impact factor: 9.933

8.  Immunostimulatory CpG on Carbon Nanotubes Selectively Inhibits Migration of Brain Tumor Cells.

Authors:  Darya Alizadeh; Ethan E White; Teresa C Sanchez; Shunan Liu; Leying Zhang; Behnam Badie; Jacob M Berlin
Journal:  Bioconjug Chem       Date:  2018-04-02       Impact factor: 4.774

9.  Size-Dependent Mechanism of Intracellular Localization and Cytotoxicity of Mono-Disperse Spherical Mesoporous Nano- and Micron-Bioactive Glass Particles.

Authors:  Yuli Li; Qing Hu; Guohou Miao; Qing Zhang; Bo Yuan; Ye Zhu; Xiaoling Fu; Xiaofeng Chen; Chuanbin Mao
Journal:  J Biomed Nanotechnol       Date:  2016-05       Impact factor: 4.099

Review 10.  Dynamics and instabilities of lipid bilayer membrane shapes.

Authors:  Zheng Shi; Tobias Baumgart
Journal:  Adv Colloid Interface Sci       Date:  2014-01-25       Impact factor: 12.984
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