| Literature DB >> 2431362 |
D M Armstrong, G Bruce, L B Hersh, R D Terry.
Abstract
We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.Entities:
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Year: 1986 PMID： 2431362 DOI： 10.1016/0304-3940(86)90564-1
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046