Literature DB >> 24311849

Effects of ethanol extract of Radix Sophorae Flavescentis on activity of colon cancer HT29 cells.

Zhi-Ming Xiao1, Ai-Min Wang2, Xiao-Yan Wang1, Shou-Rong Shen1.   

Abstract

This paper mainly studied the inhibitory effect of total ethanol extract of Radix Sophorae Flavescentis on proliferation of colon cancer HT29 cells. By reflux extraction method and with ethanol as extraction solvent, different extracts were obtained at different ethanol concentrations, different solid-liquid ratios, and at different times. And their inhibitory activities against HT29 cells were compared using MTT assay. The experimental results showed that the extraction processes under three conditions can all draw relatively high inhibition rates. The optimum ethanol extraction process conditions were as follows: a solid-liquid ratio of 1:9, 80 min of heat reflux extraction with 95% ethanol.

Entities:  

Keywords:  Orthogonal experiment; Sophora flavescens; cancer HT29; inhibition

Mesh：

Substances：

Year:  2013        PMID： 24311849      PMCID： PMC3847429          DOI： 10.4314/ajtcam.v10i5.22

Source DB:  PubMed          Journal:  Afr J Tradit Complement Altern Med        ISSN： 2505-0044


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