| Literature DB >> 2431074 |
L P Gangarosa, J M Hill, B L Thompson, C Leggett, J P Rissing.
Abstract
The cutaneous application of antiviral agents was studied by iontophoresis, a process that increases penetration of most drugs 20- to 60-fold. Twenty-seven subjects with vesicular orolabial herpes were treated one time in a double-blind, placebo-controlled clinical study: nine received vidarabine monophosphate (ara-AMP), nine received acyclovir (ACV), and nine received NaCl. Ara-AMP-treated lesions yielded lower titers of virus after 24 hr compared with lesions treated with NaCl or ACV (P less than .05). Ara-AMP significantly decreased the duration of shedding of virus (P less than .05) and time to dry crust (P less than .05) compared with the other two agents. There was a trend toward decreased healing time after ara-AMP treatment.Entities:
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Year: 1986 PMID： 2431074 DOI： 10.1093/infdis/154.6.930
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226