BACKGROUND AND PURPOSE: Whether transient global amnesia (TGA) represents an arterial insult that heralds ischemic stroke remains unclear. Therefore, we examined stroke risk after TGA in a population-based cohort. METHODS: After performing chart review at our institution to validate the International Classification of Diseases, 9th Edition, Clinical Modification diagnosis code for TGA, we used administrative claims data to identify all patients discharged from nonfederal California emergency departments or acute care hospitals between 2005 and 2010 with a primary discharge diagnosis of TGA. Patients with a primary discharge diagnosis of migraine, seizure, or transient ischemic attack were included as controls. Kaplan-Meier statistics were used to calculate rates of ischemic stroke, and Cox proportional hazards analyses were used to compare stroke risk among the 4 exposure groups while controlling for traditional stroke risk factors. RESULTS: International Classification of Diseases, 9th Edition, Clinical Modification code 437.7 had a sensitivity of 86% and a specificity of 95% for TGA. The cumulative 1-year rate of stroke was 0.54% (95% confidence interval [CI], 0.36-0.81) after TGA, 0.22% (95% CI, 0.20-0.25) after migraine, 0.90% (95% CI, 0.83-0.97) after seizure, and 4.72% (95% CI, 4.60-4.85) after transient ischemic attack. After adjustment for demographic characteristics and stroke risk factors, TGA was not associated with stroke risk when compared with migraine (hazard ratio, 0.82; 95% CI, 0.61-1.10). The likelihood of stroke after TGA was lower than after seizure (hazard ratio, 0.57; 95% CI, 0.44-0.76) or transient ischemic attack (hazard ratio, 0.27; 95% CI, 0.20-0.35). CONCLUSIONS: Compared with patients diagnosed with migraine or seizure, patients diagnosed with TGA do not seem to face a heightened risk of stroke.
BACKGROUND AND PURPOSE: Whether transient global amnesia (TGA) represents an arterial insult that heralds ischemic stroke remains unclear. Therefore, we examined stroke risk after TGA in a population-based cohort. METHODS: After performing chart review at our institution to validate the International Classification of Diseases, 9th Edition, Clinical Modification diagnosis code for TGA, we used administrative claims data to identify all patients discharged from nonfederal California emergency departments or acute care hospitals between 2005 and 2010 with a primary discharge diagnosis of TGA. Patients with a primary discharge diagnosis of migraine, seizure, or transient ischemic attack were included as controls. Kaplan-Meier statistics were used to calculate rates of ischemic stroke, and Cox proportional hazards analyses were used to compare stroke risk among the 4 exposure groups while controlling for traditional stroke risk factors. RESULTS: International Classification of Diseases, 9th Edition, Clinical Modification code 437.7 had a sensitivity of 86% and a specificity of 95% for TGA. The cumulative 1-year rate of stroke was 0.54% (95% confidence interval [CI], 0.36-0.81) after TGA, 0.22% (95% CI, 0.20-0.25) after migraine, 0.90% (95% CI, 0.83-0.97) after seizure, and 4.72% (95% CI, 4.60-4.85) after transient ischemic attack. After adjustment for demographic characteristics and stroke risk factors, TGA was not associated with stroke risk when compared with migraine (hazard ratio, 0.82; 95% CI, 0.61-1.10). The likelihood of stroke after TGA was lower than after seizure (hazard ratio, 0.57; 95% CI, 0.44-0.76) or transient ischemic attack (hazard ratio, 0.27; 95% CI, 0.20-0.35). CONCLUSIONS: Compared with patients diagnosed with migraine or seizure, patients diagnosed with TGA do not seem to face a heightened risk of stroke.
Authors: Ralph L Sacco; Scott E Kasner; Joseph P Broderick; Louis R Caplan; J J Buddy Connors; Antonio Culebras; Mitchell S V Elkind; Mary G George; Allen D Hamdan; Randall T Higashida; Brian L Hoh; L Scott Janis; Carlos S Kase; Dawn O Kleindorfer; Jin-Moo Lee; Michael E Moseley; Eric D Peterson; Tanya N Turan; Amy L Valderrama; Harry V Vinters Journal: Stroke Date: 2013-05-07 Impact factor: 7.914
Authors: Alan S Go; Dariush Mozaffarian; Véronique L Roger; Emelia J Benjamin; Jarett D Berry; William B Borden; Dawn M Bravata; Shifan Dai; Earl S Ford; Caroline S Fox; Sheila Franco; Heather J Fullerton; Cathleen Gillespie; Susan M Hailpern; John A Heit; Virginia J Howard; Mark D Huffman; Brett M Kissela; Steven J Kittner; Daniel T Lackland; Judith H Lichtman; Lynda D Lisabeth; David Magid; Gregory M Marcus; Ariane Marelli; David B Matchar; Darren K McGuire; Emile R Mohler; Claudia S Moy; Michael E Mussolino; Graham Nichol; Nina P Paynter; Pamela J Schreiner; Paul D Sorlie; Joel Stein; Tanya N Turan; Salim S Virani; Nathan D Wong; Daniel Woo; Melanie B Turner Journal: Circulation Date: 2012-12-12 Impact factor: 29.690
Authors: Peggy Quinette; Bérengère Guillery-Girard; Jacques Dayan; Vincent de la Sayette; Sophie Marquis; Fausto Viader; Béatrice Desgranges; Francis Eustache Journal: Brain Date: 2006-05-02 Impact factor: 13.501
Authors: Michael P Lerario; Alexander E Merkler; Gino Gialdini; Neal S Parikh; Babak B Navi; Hooman Kamel Journal: Stroke Date: 2016-01-07 Impact factor: 7.914
Authors: Andreas Rogalewski; Anne Beyer; Anja Friedrich; Jorge Plümer; Frédéric Zuhorn; Isabell Greeve; Randolf Klingebiel; Friedrich G Woermann; Christian G Bien; Wolf-Rüdiger Schäbitz Journal: Front Neurol Date: 2021-07-08 Impact factor: 4.003