| Literature DB >> 24309505 |
Mingzhang Gao1, Min Wang1, Qi-Huang Zheng2.
Abstract
The authentic standard T808 and its corresponding mesylate precursor T808P were synthesized in six steps using ethyl vinyl ether and trichlorocetyl chloride as starting materials. The overall chemical yields of T808 and T808P were 35% and 52%, respectively. [(18)F]-T808 was synthesized from T808P by the nucleophilic substitution with K[(18)F]F/Kryptofix 2.2.2 and isolated by HPLC combined with solid-phase extraction (SPE) purification in 35-45% radiochemical yield with 37-370GBq/μmol specific activity at end of bombardment (EOB).Entities:
Keywords: Alzheimer’s disease (AD); Automation; Positron emission tomography (PET); Tau tracer; [(18)F]-T808
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Year: 2013 PMID： 24309505 DOI： 10.1016/j.bmcl.2013.11.025
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823