Literature DB >> 24309284

Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCs.

Alicia M Pickrell1, Richard J Youle.   

Abstract

Mitochondrial diseases cause a range of clinical manifestations even in patients carrying the same mtDNA mutations. New work reveals that a common disease-associated mtDNA mutation is selectively segregated from wild-type mtDNA during the reprogramming of induced pluripotent stem cells and that high levels of this mutation in differentiated neurons upregulate Parkin-mediated mitophagy.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 24309284      PMCID： PMC4746723          DOI： 10.1016/j.cub.2013.10.048

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  16 in total

1.  The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria.

Authors:  Seok Min Jin; Richard J Youle
Journal:  Autophagy       Date:  2013-09-05       Impact factor: 16.016

2.  The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions.

Authors:  Alicia M Pickrell; Hirokazu Fukui; Xiao Wang; Milena Pinto; Carlos T Moraes
Journal:  J Neurosci       Date:  2011-07-06       Impact factor: 6.167

3.  Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model.

Authors:  Riikka H Hämäläinen; Tuula Manninen; Hanna Koivumäki; Mikhail Kislin; Timo Otonkoski; Anu Suomalainen
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-03       Impact factor: 11.205

4.  Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

Authors:  Clifford D L Folmes; Timothy J Nelson; Almudena Martinez-Fernandez; D Kent Arrell; Jelena Zlatkovic Lindor; Petras P Dzeja; Yasuhiro Ikeda; Carmen Perez-Terzic; Andre Terzic
Journal:  Cell Metab       Date:  2011-08-03       Impact factor: 27.287

5.  Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice.

Authors:  Kati J Ahlqvist; Riikka H Hämäläinen; Shuichi Yatsuga; Marko Uutela; Mügen Terzioglu; Alexandra Götz; Saara Forsström; Petri Salven; Alexandre Angers-Loustau; Outi H Kopra; Henna Tyynismaa; Nils-Göran Larsson; Kirmo Wartiovaara; Tomas Prolla; Aleksandra Trifunovic; Anu Suomalainen
Journal:  Cell Metab       Date:  2012-01-04       Impact factor: 27.287

6.  New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice.

Authors:  Liqin Cao; Hiroshi Shitara; Michihiko Sugimoto; Jun-Ichi Hayashi; Kuniya Abe; Hiromichi Yonekawa
Journal:  PLoS Genet       Date:  2009-12-04       Impact factor: 5.917

7.  Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations.

Authors:  Andrey Y Abramov; Tora K Smulders-Srinivasan; Denise M Kirby; Rebeca Acin-Perez; José Antonio Enriquez; Robert N Lightowlers; Michael R Duchen; Douglass M Turnbull
Journal:  Brain       Date:  2010-02-15       Impact factor: 13.501

8.  A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions.

Authors:  Francisca Diaz; Sofia Garcia; Kyle R Padgett; Carlos T Moraes
Journal:  Hum Mol Genet       Date:  2012-08-21       Impact factor: 6.150

9.  The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo.

Authors:  Evelyn S Vincow; Gennifer Merrihew; Ruth E Thomas; Nicholas J Shulman; Richard P Beyer; Michael J MacCoss; Leo J Pallanck
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-18       Impact factor: 11.205

10.  Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.

Authors:  Derek Narendra; Atsushi Tanaka; Der-Fen Suen; Richard J Youle
Journal:  J Cell Biol       Date:  2008-11-24       Impact factor: 10.539
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  5 in total

Review 1.  Pluripotent stem cell energy metabolism: an update.

Authors:  Tara Teslaa; Michael A Teitell
Journal:  EMBO J       Date:  2014-12-04       Impact factor: 11.598

Review 2.  Mitochondrial DNA Dynamics in Reprogramming to Pluripotency.

Authors:  Alexander J Sercel; Natasha M Carlson; Alexander N Patananan; Michael A Teitell
Journal:  Trends Cell Biol       Date:  2021-04       Impact factor: 21.167

3.  An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation.

Authors:  Max E Harner; Ann-Katrin Unger; Willie Jc Geerts; Muriel Mari; Toshiaki Izawa; Maria Stenger; Stefan Geimer; Fulvio Reggiori; Benedikt Westermann; Walter Neupert
Journal:  Elife       Date:  2016-11-16       Impact factor: 8.140

Review 4.  Advances in mt-tRNA Mutation-Caused Mitochondrial Disease Modeling: Patients' Brain in a Dish.

Authors:  Suleva Povea-Cabello; Marina Villanueva-Paz; Juan M Suárez-Rivero; Mónica Álvarez-Córdoba; Irene Villalón-García; Marta Talaverón-Rey; Alejandra Suárez-Carrillo; Manuel Munuera-Cabeza; José A Sánchez-Alcázar
Journal:  Front Genet       Date:  2021-01-12       Impact factor: 4.599

Review 5.  Gaining Insight into Mitochondrial Genetic Variation and Downstream Pathophysiology: What Can i(PSCs) Do?

Authors:  Jesse D Moreira; Deepa M Gopal; Darrell N Kotton; Jessica L Fetterman
Journal:  Genes (Basel)       Date:  2021-10-22       Impact factor: 4.096
  5 in total

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