Yen-Yu Ian Shih1, Tiwari V Yash2, Bill Rogers3, Timothy Q Duong4. 1. Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC 27599, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: shihy@unc.edu. 2. Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA. 3. Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. 4. Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; South Texas Veterans Health Care System, Department of Veterans Affairs, USA. Electronic address: duongt@uthscsa.edu.
Abstract
BACKGROUND: Functional magnetic resonance imaging (fMRI) of deep brain stimulation (DBS) has potentials to reveal neuroanatomical connectivity of a specific brain region in vivo. OBJECTIVE: This study aimed to demonstrate frequency and amplitude tunings of the thalamocortical tract using DBS fMRI at the rat ventral posteromedial thalamus. METHODS: Blood oxygenation level dependent (BOLD) fMRI data were acquired in a total of twelve rats at a high-field 11.7 T MRI scanner with modulation of nine stimulus frequencies (1-40 Hz) and seven stimulus amplitudes (0.2-3.6 mA). RESULTS: BOLD response in the barrel cortex peaked at 25 Hz. The response increased with stimulus amplitude and reached a plateau at 1 mA. Cortical spreading depolarization (CSD) was observed occasionally after DBS that carries >10% BOLD waves spanning the entire ipsilateral cortex. CONCLUSION: fMRI is sensitive to the frequency effect of DBS and has potential to investigate the function of a particular neuroanatomical pathway.
BACKGROUND: Functional magnetic resonance imaging (fMRI) of deep brain stimulation (DBS) has potentials to reveal neuroanatomical connectivity of a specific brain region in vivo. OBJECTIVE: This study aimed to demonstrate frequency and amplitude tunings of the thalamocortical tract using DBS fMRI at the rat ventral posteromedial thalamus. METHODS: Blood oxygenation level dependent (BOLD) fMRI data were acquired in a total of twelve rats at a high-field 11.7 T MRI scanner with modulation of nine stimulus frequencies (1-40 Hz) and seven stimulus amplitudes (0.2-3.6 mA). RESULTS: BOLD response in the barrel cortex peaked at 25 Hz. The response increased with stimulus amplitude and reached a plateau at 1 mA. Cortical spreading depolarization (CSD) was observed occasionally after DBS that carries >10% BOLD waves spanning the entire ipsilateral cortex. CONCLUSION: fMRI is sensitive to the frequency effect of DBS and has potential to investigate the function of a particular neuroanatomical pathway.
Authors: Yen-Yu I Shih; Guang Li; Eric R Muir; Bryan H De La Garza; Jeffrey W Kiel; Timothy Q Duong Journal: Magn Reson Med Date: 2011-12-19 Impact factor: 4.668
Authors: Yen-Yu I Shih; Lin Wang; Bryan H De La Garza; Guang Li; Grant Cull; Jeffery W Kiel; Timothy Q Duong Journal: Curr Eye Res Date: 2013-01-14 Impact factor: 2.424
Authors: Nathalie Van Den Berge; Vincent Keereman; Christian Vanhove; Bregt Van Nieuwenhuyse; Pieter van Mierlo; Robrecht Raedt; Kristl Vonck; Paul Boon; Roel Van Holen Journal: Mol Imaging Biol Date: 2015-06 Impact factor: 3.488
Authors: Heather K Decot; Vijay M K Namboodiri; Wei Gao; Jenna A McHenry; Joshua H Jennings; Sung-Ho Lee; Pranish A Kantak; Yu-Chieh Jill Kao; Manasmita Das; Ilana B Witten; Karl Deisseroth; Yen-Yu Ian Shih; Garret D Stuber Journal: Neuropsychopharmacology Date: 2016-08-12 Impact factor: 7.853
Authors: Nathalie Van Den Berge; Daniel L Albaugh; Andrew Salzwedel; Christian Vanhove; Roel Van Holen; Wei Gao; Garret D Stuber; Yen-Yu Ian Shih Journal: Neuroimage Date: 2016-11-05 Impact factor: 6.556
Authors: Artem Shatillo; Arto Lipponen; Raimo A Salo; Heikki Tanila; Alexei Verkhratsky; Rashid Giniatullin; Olli H Gröhn Journal: J Cereb Blood Flow Metab Date: 2018-04-25 Impact factor: 6.200
Authors: Daniel L Albaugh; Andrew Salzwedel; Nathalie Van Den Berge; Wei Gao; Garret D Stuber; Yen-Yu Ian Shih Journal: Sci Rep Date: 2016-09-07 Impact factor: 4.379