| Literature DB >> 24309000 |
Mohammad Arshad1, Abdul Roouf Bhat2, Smritee Pokharel2, Ji-Eun Kim2, Eun Ju Lee2, Fareeda Athar3, Inho Choi4.
Abstract
A series of new 1,2-substituted tetrazole derivatives were synthesized and evaluated on MCF-7 (ER positive), MDA-MB-231 and ZR-75 (ER negative) breast cancer cell lines. Out of the fourteen compounds, three compounds 10, 12 and 14 showed higher inhibitory effects on MCF-7 cells. Whereas, compound 8 exhibited higher inhibition in MDA-MB-231 and ZR-75 cells at 10(-5) M concentration. Total RNA was extracted and effect of compounds on different marker genes was studied. The gene expression of CD44, BRAC and BAX were significantly affected. The compounds were screened against the HepG2 cell line, to know if they are selectively targeting specific cancers and only 1-10 percent inhibition was found at 10(-5) M concentration.Entities:
Keywords: Anticancer; MCF-7; MDA-MB-231; Tetrazole derivatives; ZR-75
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Year: 2013 PMID： 24309000 DOI： 10.1016/j.ejmech.2013.11.008
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514