Literature DB >> 24308579

Recent progress concerning CpG DNA and its use as a vaccine adjuvant.

Hidekazu Shirota1, Dennis M Klinman.   

Abstract

CpG Oligonucleotides (ODN) are immunomodulatory synthetic oligonucleotides designed to specifically agonize Toll-like receptor 9. Here, we review recent progress in understanding the mechanism of action of CpG ODN and provide an overview of human clinical trial results using CpG ODN to improve the vaccines for cancer, allergy and infectious disease.

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Year:  2013        PMID： 24308579      PMCID： PMC6335645          DOI： 10.1586/14760584.2014.863715

Source DB:  PubMed          Journal:  Expert Rev Vaccines        ISSN： 1476-0584            Impact factor:   5.217


  161 in total

1.  Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells.

Authors:  A Krug; S Rothenfusser; V Hornung; B Jahrsdörfer; S Blackwell; Z K Ballas; S Endres; A M Krieg; G Hartmann
Journal:  Eur J Immunol       Date:  2001-07       Impact factor: 5.532

2.  Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG-tagged antigen by dendritic cells.

Authors:  H Shirota; K Sano; N Hirasawa; T Terui; K Ohuchi; T Hattori; K Shirato; G Tamura
Journal:  J Immunol       Date:  2001-07-01       Impact factor: 5.422

Review 3.  Liposomes to target the lymphatics by subcutaneous administration.

Authors:  C Oussoren; G Storm
Journal:  Adv Drug Deliv Rev       Date:  2001-08-23       Impact factor: 15.470

4.  Regulation of T-helper type 2 cell and airway eosinophilia by transmucosal coadministration of antigen and oligodeoxynucleotides containing CpG motifs.

Authors:  H Shirota; K Sano; T Kikuchi; G Tamura; K Shirato
Journal:  Am J Respir Cell Mol Biol       Date:  2000-02       Impact factor: 6.914

5.  Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator.

Authors:  H Shirota; K Sano; T Kikuchi; G Tamura; K Shirato
Journal:  J Immunol       Date:  2000-06-01       Impact factor: 5.422

6.  Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo.

Authors:  G Hartmann; R D Weeratna; Z K Ballas; P Payette; S Blackwell; I Suparto; W L Rasmussen; M Waldschmidt; D Sajuthi; R H Purcell; H L Davis; A M Krieg
Journal:  J Immunol       Date:  2000-02-01       Impact factor: 5.422

7.  Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism.

Authors:  H J Cho; K Takabayashi; P M Cheng; M D Nguyen; M Corr; S Tuck; E Raz
Journal:  Nat Biotechnol       Date:  2000-05       Impact factor: 54.908

8.  Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs.

Authors:  D Verthelyi; K J Ishii; M Gursel; F Takeshita; D M Klinman
Journal:  J Immunol       Date:  2001-02-15       Impact factor: 5.422

9.  Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity.

Authors:  H Tighe; K Takabayashi; D Schwartz; G Van Nest; S Tuck; J J Eiden; A Kagey-Sobotka; P S Creticos; L M Lichtenstein; H L Spiegelberg; E Raz
Journal:  J Allergy Clin Immunol       Date:  2000-07       Impact factor: 10.793

10.  Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys.

Authors:  T R Jones; N Obaldia; R A Gramzinski; Y Charoenvit; N Kolodny; S Kitov; H L Davis; A M Krieg; S L Hoffman
Journal:  Vaccine       Date:  1999-08-06       Impact factor: 3.641
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  59 in total

Review 1.  Liposomes as vaccine delivery systems: a review of the recent advances.

Authors:  Reto A Schwendener
Journal:  Ther Adv Vaccines       Date:  2014-11

2.  Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants.

Authors:  Melissa C Hanson; Monica P Crespo; Wuhbet Abraham; Kelly D Moynihan; Gregory L Szeto; Stephanie H Chen; Mariane B Melo; Stefanie Mueller; Darrell J Irvine
Journal:  J Clin Invest       Date:  2015-05-04       Impact factor: 14.808

3.  Self-Assembly of Immune Signals Improves Codelivery to Antigen Presenting Cells and Accelerates Signal Internalization, Processing Kinetics, and Immune Activation.

Authors:  Michelle L Bookstaver; Krystina L Hess; Christopher M Jewell
Journal:  Small       Date:  2018-08-26       Impact factor: 13.281

Review 4.  mRNA vaccine delivery using lipid nanoparticles.

Authors:  Andreas M Reichmuth; Matthias A Oberli; Ana Jaklenec; Robert Langer; Daniel Blankschtein
Journal:  Ther Deliv       Date:  2016

Review 5.  Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Vaccination Strategies Based on NK Cell and ILC Memory.

Authors:  Megan A Cooper; Todd A Fehniger; Marco Colonna
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-10-01       Impact factor: 10.005

Review 6.  Self-dsDNA in the pathogenesis of systemic lupus erythematosus.

Authors:  Y Bai; Y Tong; Y Liu; H Hu
Journal:  Clin Exp Immunol       Date:  2017-09-15       Impact factor: 4.330

7.  CpG-PEG Conjugates and their Immune Modulating Effects after Systemic Administration.

Authors:  Caixing Wu; Xiaofei Xiang; Yang Yue; Lin Li; Yesen Li; Chong Zhang; Yuhong Xu
Journal:  Pharm Res       Date:  2018-03-02       Impact factor: 4.200

8.  Design of Polyelectrolyte Multilayers to Promote Immunological Tolerance.

Authors:  Lisa H Tostanoski; Yu-Chieh Chiu; James I Andorko; Ming Guo; Xiangbin Zeng; Peipei Zhang; Walter Royal; Christopher M Jewell
Journal:  ACS Nano       Date:  2016-09-07       Impact factor: 15.881

9.  Polyplexes assembled from self-peptides and regulatory nucleic acids blunt toll-like receptor signaling to combat autoimmunity.

Authors:  Krystina L Hess; James I Andorko; Lisa H Tostanoski; Christopher M Jewell
Journal:  Biomaterials       Date:  2016-11-30       Impact factor: 12.479

Review 10.  Immunostimulatory biomaterials to boost tumor immunogenicity.

Authors:  Oluwaseyi T Shofolawe-Bakare; Larry D Stokes; Mehjabeen Hossain; Adam E Smith; Thomas A Werfel
Journal:  Biomater Sci       Date:  2020-09-02       Impact factor: 6.843
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