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Literature DB >> 2430835

Inhibition of a calcium-activated, non-selective cation channel, in a rat insulinoma cell line, by adenine derivatives.

Abstract

The effects of adenosine and adenine nucleotides on a calcium-activated non-selective cation channel, present in the plasma membrane of an insulin-secreting cell line CRI-Gl were investigated. Single-channel currents were recorded from inside-out membrane patches and the adenine derivatives applied to the solution bathing the cytoplasmic aspect of the membrane surface. The activity of this channel is shown to be inhibited by all the derivatives tested. The potency sequence for inhibition was found to be AMP greater than ADP greater than ATP greater than adenosine.

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Year: 1986 PMID： 2430835 DOI： 10.1016/0014-5793(86)81056-0

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

23 in total

Review 1. Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans.

Authors: L S Satin
Journal: Endocrine Date: 2000-12 Impact factor: 3.633

2. Regulation by voltage and adenine nucleotides of a Ca2+-activated cation channel from hamster vomeronasal sensory neurons.

Authors: Emily R Liman
Journal: J Physiol Date: 2003-03-14 Impact factor: 5.182

3. Effect of parathyroid hormone on the connecting tubule from the rabbit kidney: biphasic response of transmural voltage.

Authors: T Shimizu; K Yoshitomi; M Nakamura; M Imai
Journal: Pflugers Arch Date: 1990-05 Impact factor: 3.657

4. Regulation of a non-selective cation channel of cultured porcine coronary artery smooth muscle cells by tyrosine kinase.

Authors: K Minami; K Fukuzawa; I Inoue
Journal: Pflugers Arch Date: 1994-02 Impact factor: 3.657

10. Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1.

Authors: G G Holz; C A Leech; J F Habener
Journal: J Biol Chem Date: 1995-07-28 Impact factor: 5.157

Inhibition of a calcium-activated, non-selective cation channel, in a rat insulinoma cell line, by adenine derivatives.

Review 1. Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans.

2. Regulation by voltage and adenine nucleotides of a Ca2+-activated cation channel from hamster vomeronasal sensory neurons.

3. Effect of parathyroid hormone on the connecting tubule from the rabbit kidney: biphasic response of transmural voltage.

4. Regulation of a non-selective cation channel of cultured porcine coronary artery smooth muscle cells by tyrosine kinase.

5. A cation channel in the thick ascending limb of Henle's loop of the mouse kidney: inhibition by adenine nucleotides.

6. Calcium and ATP regulate the activity of a non-selective cation channel in a rat insulinoma cell line.

7. Adenosine-5'-triphosphate-sensitive ion channels in neonatal rat cultured central neurones.

8. Nucleotide-sensitive ion channels in human insulin producing tumour cells.

9. Effects of internal pH on the nonselective cation channel from the mouse collecting tubule.

10. Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1.