Nicolas Jung1, Frédéric Bertrand, Seiamak Bahram, Laurent Vallat, Myriam Maumy-Bertrand. 1. INSERM UMR S_1109, Labex Transplantex, FMTS, Hôpitaux and Faculté de Médecine, Université de Strasbourg, 67085 Strasbourg Cedex and IRMA, CNRS UMR 7501, Labex IRMIA, Université de Strasbourg, 67084 Strasbourg Cedex, France.
Abstract
SUMMARY: Temporal gene interactions, in response to environmental stress, form a complex system that can be efficiently described using gene regulatory networks. They allow highlighting the more influential genes and spotting some targets for biological intervention experiments. Despite that many reverse engineering tools have been designed, the Cascade package is an integrated solution adding several new and original key features such as the ability to predict changes in gene expressions after a biological perturbation in the network and graphical outputs that allow monitoring the spread of a signal through the network. AVAILABILITY AND IMPLEMENTATION: The R package Cascade is available online at http://www-math.u-strasbg.fr/genpred/spip.php?rubrique4.
SUMMARY: Temporal gene interactions, in response to environmental stress, form a complex system that can be efficiently described using gene regulatory networks. They allow highlighting the more influential genes and spotting some targets for biological intervention experiments. Despite that many reverse engineering tools have been designed, the Cascade package is an integrated solution adding several new and original key features such as the ability to predict changes in gene expressions after a biological perturbation in the network and graphical outputs that allow monitoring the spread of a signal through the network. AVAILABILITY AND IMPLEMENTATION: The R package Cascade is available online at http://www-math.u-strasbg.fr/genpred/spip.php?rubrique4.