Literature DB >> 24307504

Carborane-based carbonic anhydrase inhibitors.

Jiří Brynda1, Pavel Mader, Václav Šícha, Milan Fábry, Kristýna Poncová, Mario Bakardiev, Bohumír Grüner, Petr Cígler, Pavlína Řezáčová.   

Abstract

CA inhibitors: Human carbonic anhydrases (CAs) are diagnostic and therapeutic targets. Various carborane cages are shown to act as active-site-directed inhibitors, and substitution with a sulfamide group and other substituents leads to compounds with high selectivity towards the cancer-specific isozyme IX. Crystal structures of the carboranes in the active site provide information that can be applied to the structure-based design of specific inhibitors.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  carbonic anhydrases; carboranes; drug discovery; inhibitors; structure elucidation

Mesh：

Substances：

Year:  2013        PMID： 24307504     DOI： 10.1002/anie.201307583

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  9 in total

1.  nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2.

Authors:  Wilma Neumann; Shu Xu; Menyhárt B Sárosi; Matthias S Scholz; Brenda C Crews; Kebreab Ghebreselasie; Surajit Banerjee; Lawrence J Marnett; Evamarie Hey-Hawkins
Journal:  ChemMedChem       Date:  2015-06-18       Impact factor: 3.466

2.  Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors.

Authors:  Kai Li; Yang Wang; Gyongseon Yang; Sooyoung Byun; Guodong Rao; Carolyn Shoen; Hongliang Yang; Anmol Gulati; Dean C Crick; Michael Cynamon; Guozhong Huang; Roberto Docampo; Joo Hwan No; Eric Oldfield
Journal:  ACS Infect Dis       Date:  2015-05-08       Impact factor: 5.084

3.  Pd(ii)-catalyzed synthesis of bifunctionalized carboranes via cage B-H activation of 1-CH2NH2-o-carboranes.

Authors:  Xiaolei Zhang; Hong Yan
Journal:  Chem Sci       Date:  2018-03-27       Impact factor: 9.825

4.  Carborane-based carbonic anhydrase inhibitors: insight into CAII/CAIX specificity from a high-resolution crystal structure, modeling, and quantum chemical calculations.

Authors:  Pavel Mader; Adam Pecina; Petr Cígler; Martin Lepšík; Václav Šícha; Pavel Hobza; Bohumír Grüner; Jindřich Fanfrlík; Jiří Brynda; Pavlína Řezáčová
Journal:  Biomed Res Int       Date:  2014-09-18       Impact factor: 3.411

5.  Interactions of Boron Clusters and their Derivatives with Serum Albumin.

Authors:  Tomasz M Goszczyński; Krzysztof Fink; Konrad Kowalski; Zbigniew J Leśnikowski; Janusz Boratyński
Journal:  Sci Rep       Date:  2017-08-29       Impact factor: 4.379

6.  DNA-linked Inhibitor Antibody Assay (DIANA) for sensitive and selective enzyme detection and inhibitor screening.

Authors:  Václav Navrátil; Jiří Schimer; Jan Tykvart; Tomáš Knedlík; Viktor Vik; Pavel Majer; Jan Konvalinka; Pavel Šácha
Journal:  Nucleic Acids Res       Date:  2016-09-26       Impact factor: 16.971

7.  The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX.

Authors:  Michael Kugler; Josef Holub; Jiří Brynda; Klára Pospíšilová; Suzan El Anwar; Dmytro Bavol; Miroslav Havránek; Vlastimil Král; Milan Fábry; Bohumír Grüner; Pavlína Řezáčová
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

8.  In vitro and in vivo BNCT investigations using a carborane containing sulfonamide targeting CAIX epitopes on malignant pleural mesothelioma and breast cancer cells.

Authors:  Diego Alberti; Alessia Michelotti; Alberto Lanfranco; Nicoletta Protti; Saverio Altieri; Annamaria Deagostino; Simonetta Geninatti Crich
Journal:  Sci Rep       Date:  2020-11-06       Impact factor: 4.379

Review 9.  The Boron Advantage: The Evolution and Diversification of Boron's Applications in Medicinal Chemistry.

Authors:  Katia Messner; Billy Vuong; Geoffrey K Tranmer
Journal:  Pharmaceuticals (Basel)       Date:  2022-02-22
  9 in total

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