Literature DB >> 24307493

Bioorthogonal chemistry for (68) Ga radiolabelling of DOTA-containing compounds.

Helen L Evans1, Laurence Carroll, Eric O Aboagye, Alan C Spivey.   

Abstract

Copper-catalysed 'click' chemistry is a highly utilised technique for radiolabelling small molecules and peptides for imaging applications. The usefulness of these reactions falls short, however, when metal catalysis is not a practically viable route; such as when using metal chelates as radioligands. Here, we describe a method for carrying out 'click-type' radiochemistry in the presence of DOTA chelates, by combining (68) Ga radiolabelling techniques with well-established bioorthogonal reactions, which do not rely upon metal catalysis.
Copyright © 2013 John Wiley & Sons, Ltd.

Entities:  

Keywords:  Bioorthogonal chemistry; DOTA; Gallium-68; azide; click chemistry; cyclooctyne; norbornene; strained alkene; tetrazine

Mesh：

Substances：

Year:  2013        PMID： 24307493     DOI： 10.1002/jlcr.3153

Source DB:  PubMed          Journal:  J Labelled Comp Radiopharm        ISSN： 0362-4803            Impact factor:   1.921


  7 in total

Review 1.  Click Chemistry and Radiochemistry: The First 10 Years.

Authors:  Jan-Philip Meyer; Pierre Adumeau; Jason S Lewis; Brian M Zeglis
Journal:  Bioconjug Chem       Date:  2016-11-22       Impact factor: 4.774

2.  Conformationally Strained trans-Cyclooctene (sTCO) Enables the Rapid Construction of (18)F-PET Probes via Tetrazine Ligation.

Authors:  Mengzhe Wang; Dennis Svatunek; Katarina Rohlfing; Yu Liu; Hui Wang; Ben Giglio; Hong Yuan; Zhanghong Wu; Zibo Li; Joseph Fox
Journal:  Theranostics       Date:  2016-04-12       Impact factor: 11.556

3.  A Pretargeted Approach for the Multimodal PET/NIRF Imaging of Colorectal Cancer.

Authors:  Pierre Adumeau; Kathryn E Carnazza; Christian Brand; Sean D Carlin; Thomas Reiner; Brian J Agnew; Jason S Lewis; Brian M Zeglis
Journal:  Theranostics       Date:  2016-09-28       Impact factor: 11.556

Review 4.  Bio-orthogonal Fluorescent Labelling of Biopolymers through Inverse-Electron-Demand Diels-Alder Reactions.

Authors:  Eszter Kozma; Orsolya Demeter; Péter Kele
Journal:  Chembiochem       Date:  2017-02-01       Impact factor: 3.164

5.  iEDDA Conjugation Reaction in Radiometal Labeling of Peptides with 68Ga and 64Cu: Unexpected Findings.

Authors:  Shanna Litau; Uwe Seibold; Björn Wängler; Ralf Schirrmacher; Carmen Wängler
Journal:  ACS Omega       Date:  2018-10-25

Review 6.  Recent Advances in Bioorthogonal Click Chemistry for Efficient Synthesis of Radiotracers and Radiopharmaceuticals.

Authors:  Sajid Mushtaq; Seong-Jae Yun; Jongho Jeon
Journal:  Molecules       Date:  2019-10-02       Impact factor: 4.411

7.  Evaluation of a 68Ga-Labeled DOTA-Tetrazine as a PET Alternative to 111In-SPECT Pretargeted Imaging.

Authors:  Patricia E Edem; Jesper T Jørgensen; Kamilla Nørregaard; Rafaella Rossin; Abdolreza Yazdani; John F Valliant; Marc Robillard; Matthias M Herth; Andreas Kjaer
Journal:  Molecules       Date:  2020-01-22       Impact factor: 4.411
  7 in total

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