| Literature DB >> 2430671 |
P J Elliott, C B Nemeroff, C D Kilts.
Abstract
Microinjections of a monoclonal antibody against substance P (SP) into the nucleus accumbens (NAS) increased the concentrations of dopamine (DA) and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in the NAS but not in neuroanatomically adjacent areas. SP immunoneutralization in the NAS also reduced the locomotor response to systemically administered D-amphetamine. Microinjections of control antibody did not significantly alter either DA metabolism or D-amphetamine-induced locomotion. These data are consistent with the hypothesis that endogenous SP modulates the release of DA in the NAS.Entities:
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Year: 1986 PMID： 2430671 DOI： 10.1016/0006-8993(86)91087-5
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252