| Literature DB >> 24306323 |
Matias V Madsen1, Anders M Donatsky, Bente R Jensen, Jacob Rosenberg, Karsten P Hammelev, Mona R Gätke.
Abstract
Intense neuromuscular blockade (NMB) measured by post tetanic count (PTC) was monitored, reversed and verified in this pig model. In a cross-over assessor blinded design six pigs were randomized to either no NMB followed by intense NMB, or intense NMB followed by no NMB. Neuromuscular measurements were performed with acceleromyography [train-of-four (TOF) Watch SX]. In all pigs, the response to TOF nerve stimulation was stable and intense NMB (PTC 0-1) was established with rocuronium 3 mg/kg. For reversal, the pigs received sugammadex 20-35 mg/kg and returned to TOF-ratio above 0.90 within 2.15 min after injection. We established a pig model for monitoring intense NMB with surface stimulation electrodes and acceleromyography. We verified total relaxation of the diaphragm and the abdominal muscles at the PTC 0-1 by suction test and with surface electromyography. This pig model is suitable for studies with experimental abdominal surgery with monitoring of intense NMB, and where relaxation of the diaphragm and the abdominal muscles are required.Entities:
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Year: 2013 PMID： 24306323 DOI： 10.1007/s10877-013-9539-1
Source DB: PubMed Journal: J Clin Monit Comput ISSN： 1387-1307 Impact factor: 2.502