Literature DB >> 24304913

A mediator methylation mystery: JMJD1C demethylates MDC1 to regulate DNA repair.

Jian Lu1, Michael J Matunis.   

Abstract

Mediator of DNA-damage checkpoint 1 (MDMDC1) has a central role in repair of DNA double-strand breaks (DSBs) by both homologous recombination and nonhomologous end joining, and its function is regulated by post-translational phosphorylation, ubiquitylation and sumoylation. In this issue, a new study by Watanabe et al. reveals that methylation of MDMDC1 is also critical for its function in DSB repair and specifically affects repair through BRCA1-dependent homologous recombination.

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Year:  2013        PMID： 24304913      PMCID： PMC4131721          DOI： 10.1038/nsmb.2729

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  17 in total

Review 1.  Close encounters of the RNF8th kind: when chromatin meets DNA repair.

Authors:  Martijn S Luijsterburg; Haico van Attikum
Journal:  Curr Opin Cell Biol       Date:  2012-03-29       Impact factor: 8.382

2.  RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.

Authors:  Frédérick A Mallette; Francesca Mattiroli; Gaofeng Cui; Leah C Young; Michael J Hendzel; Georges Mer; Titia K Sixma; Stéphane Richard
Journal:  EMBO J       Date:  2012-02-28       Impact factor: 11.598

Review 3.  Histone methylation: a dynamic mark in health, disease and inheritance.

Authors:  Eric L Greer; Yang Shi
Journal:  Nat Rev Genet       Date:  2012-04-03       Impact factor: 53.242

4.  The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks.

Authors:  Klara Acs; Martijn S Luijsterburg; Leena Ackermann; Florian A Salomons; Thorsten Hoppe; Nico P Dantuma
Journal:  Nat Struct Mol Biol       Date:  2011-11-27       Impact factor: 15.369

Review 5.  The cellular response to DNA damage: a focus on MDC1 and its interacting proteins.

Authors:  Gideon Coster; Michal Goldberg
Journal:  Nucleus       Date:  2009-12-29       Impact factor: 4.197

Review 6.  53BP1: pro choice in DNA repair.

Authors:  Michal Zimmermann; Titia de Lange
Journal:  Trends Cell Biol       Date:  2013-10-04       Impact factor: 20.808

7.  Lysine acetylation targets protein complexes and co-regulates major cellular functions.

Authors:  Chunaram Choudhary; Chanchal Kumar; Florian Gnad; Michael L Nielsen; Michael Rehman; Tobias C Walther; Jesper V Olsen; Matthias Mann
Journal:  Science       Date:  2009-07-16       Impact factor: 47.728

8.  Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.

Authors:  Nadine K Kolas; J Ross Chapman; Shinichiro Nakada; Jarkko Ylanko; Richard Chahwan; Frédéric D Sweeney; Stephanie Panier; Megan Mendez; Jan Wildenhain; Timothy M Thomson; Laurence Pelletier; Stephen P Jackson; Daniel Durocher
Journal:  Science       Date:  2007-11-15       Impact factor: 47.728

9.  RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

Authors:  Yaron Galanty; Rimma Belotserkovskaya; Julia Coates; Stephen P Jackson
Journal:  Genes Dev       Date:  2012-06-01       Impact factor: 11.361

10.  SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage.

Authors:  Yili Yin; Anne Seifert; Joy Shijia Chua; Jean-François Maure; Filip Golebiowski; Ronald T Hay
Journal:  Genes Dev       Date:  2012-06-01       Impact factor: 11.361
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  6 in total

1.  Evolution and conservation of JmjC domain proteins in the green lineage.

Authors:  Yong Huang; Donghong Chen; Chunlin Liu; Wenhui Shen; Ying Ruan
Journal:  Mol Genet Genomics       Date:  2015-07-08       Impact factor: 3.291

Review 2.  DNA damage response and repair pathway modulation by non-histone protein methylation: implications in neurodegeneration.

Authors:  Madhusoodanan Urulangodi; Abhishek Mohanty
Journal:  J Cell Commun Signal       Date:  2019-11-20       Impact factor: 5.782

3.  Pleiotropic effects of n-6 and n-3 fatty acid-related genetic variants on circulating hemostatic variables.

Authors:  Lu-Chen Weng; Weihua Guan; Lyn M Steffen; James S Pankow; Nathan Pankratz; Ming-Huei Chen; Mary Cushman; Saonli Basu; Aaron R Folsom; Weihong Tang
Journal:  Thromb Res       Date:  2018-06-01       Impact factor: 3.944

4.  Genetics of non-conventional lipoprotein fractions.

Authors:  Alexis C Frazier-Wood
Journal:  Curr Genet Med Rep       Date:  2015-08-29

5.  Histone Modifier Genes Alter Conotruncal Heart Phenotypes in 22q11.2 Deletion Syndrome.

Authors:  Tingwei Guo; Jonathan H Chung; Tao Wang; Donna M McDonald-McGinn; Wendy R Kates; Wanda Hawuła; Karlene Coleman; Elaine Zackai; Beverly S Emanuel; Bernice E Morrow
Journal:  Am J Hum Genet       Date:  2015-11-19       Impact factor: 11.025

6.  SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease.

Authors:  Salman Ahmad Mustfa; Mukesh Singh; Aamir Suhail; Gayatree Mohapatra; Smriti Verma; Debangana Chakravorty; Sarika Rana; Ritika Rampal; Atika Dhar; Sudipto Saha; Vineet Ahuja; C V Srikanth
Journal:  Open Biol       Date:  2017-06       Impact factor: 6.411
  6 in total

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