Literature DB >> 2430359

Simultaneous activation by 5-azacytidine of intracisternal R particles and murine intracisternal-A particle related sequences in Syrian hamster cells.

J Lesser, J Lasneret, M Canivet, R Emanoil-Ravier, J Périès.   

Abstract

5-Azacytidine treatment of Syrian hamster (Mesocricetus auratus) cells, BHK21-cl.13, and primary embryo fibroblasts, activates the production of intracisternal type R particles (IRP) as ascertained by electron microscopy scanning and counting. Efficiency of the activation is dose- and time of treatment-dependent. The transcription of mouse intracisternal A particle (IAP) related sequences, which have been described in Syrian hamster genomic DNA, is increased at the same time. This correlates with demethylation of hamster IAP related genes, as shown by restriction of high molecular weight DNA from 5-azacytidine treated cells with methylation sensitive enzymes, and subsequent electrophoresis and molecular hybridization of the fragments with specific DNA probes. In 5-azacytidine treated cells derived from other hamster species (Cricetulus griseus and C. migratorius), intracisternal R particles were not induced, nor were mouse IAP-related RNAs detected.

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Year:  1986        PMID： 2430359     DOI： 10.1016/0042-6822(86)90184-4

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  6 in total

1.  Molecular cloning and characterization of a complete Chinese hamster provirus related to intracisternal A particle genomes.

Authors:  A J Dorner; F Bonneville; R Kriz; K Kelleher; K Bean; R J Kaufman
Journal:  J Virol       Date:  1991-09       Impact factor: 5.103

2.  Intracisternal A particle gene related sequences are present in multiple copies in normal tissues and tumors of Mastomys natalensis (Muridae).

Authors:  J Lesser; Y J Ganem; J J Kupiec; J M Launay; J Périès
Journal:  Nucleic Acids Res       Date:  1988-01-25       Impact factor: 16.971

3.  Biological and molecular studies on Syrian hamster intracisternal R-type particles.

Authors:  J Lesser; P Bittoun; R Emanoil-Ravier; J Peries
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574

4.  Stage-specific expression of intracisternal A-particle sequences in murine myelomonocytic leukemia cell lines and normal myelomonocytic differentiation.

Authors:  Y Takayama; M A O'Mara; K Spilsbury; R Thwaite; P B Rowe; G Symonds
Journal:  J Virol       Date:  1991-04       Impact factor: 5.103

5.  Intracisternal A-type particle-mediated activations of cytokine genes in a murine myelomonocytic leukemia: generation of functional cytokine mRNAs by retroviral splicing events.

Authors:  K B Leslie; F Lee; J W Schrader
Journal:  Mol Cell Biol       Date:  1991-11       Impact factor: 4.272

6.  Nucleotide sequence of a complete mouse intracisternal A-particle genome: relationship to known aspects of particle assembly and function.

Authors:  J A Mietz; Z Grossman; K K Lueders; E L Kuff
Journal:  J Virol       Date:  1987-10       Impact factor: 6.549
  6 in total

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