[Iron-sulfur respiratory chain centers, ribonucleotide reductase activity and biosynthesis of macromolecules in the spleen of mice during acute radiation injury].

The functional status of iron-sulphur centers (ISC) of mitochondrial electron transport chain, ribonucleotide reductase (RR) activity and macromolecule biosynthesis in mouse spleen were studied during acute radiation sickness induced by whole-body gamma-irradiation of mice with a dose of 6 Gy. The ESR signal of active RR was registered in the spleen; the RR activity dynamics during acute radiation sickness was described. The RR activity was inhibited at early post-irradiation times (from 30 min to 12 h). Drastic inhibition of DNA biosynthesis and stimulation of transcription were registered. The increase in the RR activity and ISC content, which occurred 1-3 days following irradiation, was associated with the increase in the rate of protein biosynthesis.