Literature DB >> 2430239

Excitatory action of BAYK8644 on hippocampal pyramidal neurones of the guinea pig in vitro.

R J Docherty, D A Brown.   

Abstract

BAYK8944, a calcium 'agonist' caused a slow depolarization of a proportion of CA1 hippocampal pyramidal cells and increased their input resistance. In voltage-clamped CA1 neurones BAYK8644 caused a decrease in depolarization-activated outward current. Reduction of depolarization-activated outward current was also produced by the Ca ionophore A23187. It is proposed that BAYK8644 and A23187 may cause suppression of outward current secondary to a prolonged increase in cytosolic Ca activity.

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Year:  1986        PMID： 2430239     DOI： 10.1016/0304-3940(86)90470-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  2 in total

1.  The effects of chronic treatment with the dihydropyridine, Bay K 8644, on hyperexcitability due to ethanol withdrawal, in vivo and in vitro.

Authors:  M A Whittington; A R Butterworth; S J Dolin; T L Patch; H J Little
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

2.  Dihydropyridines alter adenosine sensitivity in the rat hippocampal slice.

Authors:  J T Bartrup; T W Stone
Journal:  Br J Pharmacol       Date:  1990-09       Impact factor: 8.739
  2 in total

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