| Literature DB >> 24299878 |
A V Volod'ko1, V N Davydova, E Chusovitin, I V Sorokina, M P Dolgikh, T G Tolstikova, S A Balagan, N G Galkin, I M Yermak.
Abstract
The soluble polyelectrolyte complexes (PEC) κ-carrageenan (κ-CG):chitosan was obtained. Binding constant value (2.11 × 10(7)mol(-1)) showed high affinity of κ-CG to chitosan. The complex formation of κ-CG:chitosan 1:10 and 10:1 w/w was shown by centrifugation in a Percoll gradient. Using atomic force microscopy we showed that the supramolecular structure of the complexes is different from each other and from the macromolecular structure of the initial polysaccharides. The gastroprotective and anti-ulcerogenic effect of κ-CG, chitosan and their complexes was investigated on the model of stomach ulcers induced by indometacin in rats. PEC κ-CG:chitosan have gastroprotective properties which depend on their composition. Complex κ-CG:chitosan 1:10 w/w possesses higher gastroprotective activity than the complex 10:1 w/w. These results suggest that the gastroprotective effect of complexes can be associated with their protective layer on the surface of the mucous membrane of a stomach, which avoids a direct contact with the ulcerogenic agent.Entities:
Keywords: AFM; Carrageenan; Chitosan; Gastroprotective activity; Polyelectrolyte complex; Supramolecular structure
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Year: 2013 PMID： 24299878 DOI： 10.1016/j.carbpol.2013.10.049
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381