INTRODUCTION: Tuberculosis (TB) is a common and a deadly infectious disease which is caused by Mycobacterium tuberculi. Inflammatory cytokines play an important role during the course of the disease and they may be responsible for tissue damage which is caused by lipid peroxidation. METHOD: The present study was conducted in the Department of Biochemistry and patients were selected from Department of TB and Chest Sri Aurobindo Institute of Medical Sciences and also from Manorama Raje Tuberculosis Hospital, Indore. 32 healthy controls and 35 pulmonary TB patients were compared initially for their serum Malondialdehyde (MDA) and tumour necrosis factor alpha (TNF α) levels. Serum TNF α and MDA levels were correlated. RESULT: TNF α and MDA levels in serum were significantly increased (p<0.001) in pulmonary tuberculosis patients as compared to those of controls. Increased Serum TNF α was positively correlated to MDA levels and it was found to be statistically not significant (correlation coefficient r =0.282,p> 0.05 ). CONCLUSION: The present study supports the view that there may be a link between lipid peroxidation and cytokine response and relative roles of cytokines and lipid peroxidation in the pathogenesis of tuberculosis.
INTRODUCTION:Tuberculosis (TB) is a common and a deadly infectious disease which is caused by Mycobacterium tuberculi. Inflammatory cytokines play an important role during the course of the disease and they may be responsible for tissue damage which is caused by lipid peroxidation. METHOD: The present study was conducted in the Department of Biochemistry and patients were selected from Department of TB and Chest Sri Aurobindo Institute of Medical Sciences and also from Manorama Raje Tuberculosis Hospital, Indore. 32 healthy controls and 35 pulmonary TB patients were compared initially for their serum Malondialdehyde (MDA) and tumour necrosis factor alpha (TNF α) levels. Serum TNF α and MDA levels were correlated. RESULT: TNF α and MDA levels in serum were significantly increased (p<0.001) in pulmonary tuberculosispatients as compared to those of controls. Increased Serum TNF α was positively correlated to MDA levels and it was found to be statistically not significant (correlation coefficient r =0.282,p> 0.05 ). CONCLUSION: The present study supports the view that there may be a link between lipid peroxidation and cytokine response and relative roles of cytokines and lipid peroxidation in the pathogenesis of tuberculosis.
Authors: H Kawaguchi; Y Ina; S Ito; S Sato; Y Sugiura; H Tomita; N Ogisu; K Takada; M Yamamoto; M Morishita; K Yoshikawa Journal: Kekkaku Date: 1996-03
Authors: Rodrigo Ribeiro-Rodrigues; Tatiana Resende Co; John L Johnson; Fabiola Ribeiro; Moises Palaci; Ricardo T Sá; Ethel L Maciel; Fausto E Pereira Lima; Valderio Dettoni; Zahra Toossi; W Henry Boom; Reynaldo Dietze; Jerrold J Ellner; Christina S Hirsch Journal: Clin Diagn Lab Immunol Date: 2002-07