AIM: Nimesulide, a preferential COX-2 inhibitor has 20 times more selectivity towards COX-2 than that of COX-1. COX-2 selective inhibitors cause frequent nephrotoxicity and hepatotoxicity following their usage. This proposes a physiological role of COX-2 in kidney and liver. Not much attention has been focused on the role of COX-2 with respect to reproduction especially in male reproduction, and the available information is scanty. AIMs and Objectives: The present study aims to investigate the adverse effects of nimesulide in the vas deferens thereby indirectly assess the role of COX-2 in male reproductive tract. MATERIAL AND METHODS: Nimesulide was administered orally and the animals were maintained for different time periods prior to sacrifice. RESULTS: The vas deferens of nimesulide treated mice showed extensive histopathological changes such as vacoulation and exfoliation of cells in the epithelial layer. CONCLUSION: Nimesulide administration leads to cytotoxic effects suggestive of apoptosis in the vas deferens of mice.
AIM: Nimesulide, a preferential COX-2 inhibitor has 20 times more selectivity towards COX-2 than that of COX-1. COX-2 selective inhibitors cause frequent nephrotoxicity and hepatotoxicity following their usage. This proposes a physiological role of COX-2 in kidney and liver. Not much attention has been focused on the role of COX-2 with respect to reproduction especially in male reproduction, and the available information is scanty. AIMs and Objectives: The present study aims to investigate the adverse effects of nimesulide in the vas deferens thereby indirectly assess the role of COX-2 in male reproductive tract. MATERIAL AND METHODS:Nimesulide was administered orally and the animals were maintained for different time periods prior to sacrifice. RESULTS: The vas deferens of nimesulide treated mice showed extensive histopathological changes such as vacoulation and exfoliation of cells in the epithelial layer. CONCLUSION:Nimesulide administration leads to cytotoxic effects suggestive of apoptosis in the vas deferens of mice.
Authors: A Kirschenbaum; D R Liotta; S Yao; X H Liu; A P Klausner; P Unger; E Shapiro; I Leav; A C Levine Journal: J Clin Endocrinol Metab Date: 2000-09 Impact factor: 5.958
Authors: Fábio E Mingatto; Tiago Rodrigues; Acácio A Pigoso; Sérgio A Uyemura; Carlos Curti; Antonio C Santos Journal: J Pharmacol Exp Ther Date: 2002-11 Impact factor: 4.030
Authors: M L Hull; A Prentice; D Y Wang; R P Butt; S C Phillips; S K Smith; D S Charnock-Jones Journal: Hum Reprod Date: 2004-11-26 Impact factor: 6.918
Authors: M R Panara; R Padovano; M G Sciulli; G Santini; G Renda; M T Rotondo; A Pace; C Patrono; P Patrignani Journal: Clin Pharmacol Ther Date: 1998-06 Impact factor: 6.875