Literature DB >> 24298228

EPA's Stage 2 Disinfection Byproducts Rules (DBPR) and Northern Kentucky Water: An Economic and Scientific Review.

Hugh Henry1.   

Abstract

Implementation of EPA's Stage 2 Disinfection Byproducts Rules (DBPR) in Northern Kentucky will cause a water rate increase of over 25%. Hence a review was undertaken, considering both economics and science in the context of President Obama's 2009 scientific integrity directive. The rules purport to avoid up to 0.49% of new bladder cancers by reducing the levels of DBPs in drinking water - a benefit so small that failure to implement will not cause unreasonable risk to health (URTH). It suggests at most one Northern Kentucky death avoided over 17 years for a cost of $136,000,000 ($1700 per household). Even this small benefit is probably overstated. EPA finds no "causal link" between DBPs and bladder cancer, and EPA acknowledges problems with the epidemiological data used in their calculation: the data appear contradictory and inconsistent, may be skewed toward "positive" results, and suggest different cancer sites than animal studies. Two similar international agencies disagree with EPA's conclusions. The science is based on the Linear No Threshold (LNT) dose response model for DBPs, but this may not be the correct model. 83% of EPA's epidemiological data show a statistical possibility that low levels of DBPs might be beneficial or have no effect.

Entities:  

Keywords:  Chlorinated Drinking water; Disinfection byproducts (DBP); EPA Water Regulations; Hormesis; LNT model; Trihalomethane (THM)

Year:  2013        PMID: 24298228      PMCID: PMC3834744          DOI: 10.2203/dose-response.12-056.Henry

Source DB:  PubMed          Journal:  Dose Response        ISSN: 1559-3258            Impact factor:   2.658


  44 in total

Review 1.  A theory for growth hormesis.

Authors:  A R Stebbing
Journal:  Mutat Res       Date:  1998-07-17       Impact factor: 2.433

2.  Source of funding and outcome of clinical trials.

Authors:  R A Davidson
Journal:  J Gen Intern Med       Date:  1986 May-Jun       Impact factor: 5.128

Review 3.  The practice of meta-analysis.

Authors:  J C Bailar
Journal:  J Clin Epidemiol       Date:  1995-01       Impact factor: 6.437

4.  Effect of chloroform on the activities of liver enzymes in rats.

Authors:  F J Roe; N J Van Abbé
Journal:  Toxicology       Date:  1980       Impact factor: 4.221

Review 5.  Public health implications of environmental exposures.

Authors:  C T De Rosa; H R Pohl; M Williams; A A Ademoyero; C H Chou; D E Jones
Journal:  Environ Health Perspect       Date:  1998-02       Impact factor: 9.031

6.  Disinfection byproducts and bladder cancer: a pooled analysis.

Authors:  Cristina M Villanueva; Kenneth P Cantor; Sylvaine Cordier; Jouni J K Jaakkola; Will D King; Charles F Lynch; Stefano Porru; Manolis Kogevinas
Journal:  Epidemiology       Date:  2004-05       Impact factor: 4.822

7.  Safety evaluation of toothpaste containing chloroform. I. Long-term studies in mice.

Authors:  F J Roe; A K Palmer; A N Worden; N J Van Abbé
Journal:  J Environ Pathol Toxicol       Date:  1979 Jan-Feb

8.  Safety evaluation of toothpaste containing chloroform. II. Long term studies in rats.

Authors:  A K Palmer; A E Street; F J Roe; A N Worden; N J Van Abbé
Journal:  J Environ Pathol Toxicol       Date:  1979 Jan-Feb

9.  Bladder cancer, drinking water source, and tap water consumption: a case-control study.

Authors:  K P Cantor; R Hoover; P Hartge; T J Mason; D T Silverman; R Altman; D F Austin; M A Child; C R Key; L D Marrett
Journal:  J Natl Cancer Inst       Date:  1987-12       Impact factor: 13.506

10.  Meta-analysis in cancer epidemiology.

Authors:  R D Morris
Journal:  Environ Health Perspect       Date:  1994-11       Impact factor: 9.031

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