Literature DB >> 24297491

Hemagglutinin variants of influenza A(H1N1)pdm09 virus with reduced affinity for sialic acid receptors.

G Ayora-Talavera1, L Cetina-Montejo, A Matos-Patrón, L Romero-Beltrán.   

Abstract

In influenza A H1 virus, amino acids at position 190 and 225 of HA affect replication and transmission. In this study, we show that the mutation D190Y in the HA of influenza AH1N1pdm09 virus reduces the affinity of the virus for sialic acid receptors expressed at the surface of red blood cells from different species without affecting virus replication in MDCK cells.

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Year:  2013        PMID: 24297491     DOI: 10.1007/s00705-013-1934-x

Source DB:  PubMed          Journal:  Arch Virol        ISSN: 0304-8608            Impact factor:   2.574


  2 in total

1.  Bioassay-Guided Fractionation of Erythrostemon yucatanensis (Greenm.) Gagnon & GP Lewis Components with Anti-hemagglutinin Binding Activity against Influenza A/H1N1 Virus.

Authors:  Tania Ortiz-López; Rocío Borges-Argáez; Guadalupe Ayora-Talavera; Ernesto Canto-Ramírez; Lisseth Cetina-Montejo; Ángel May-May; Fabiola Escalante-Erosa; Mirbella Cáceres-Farfán
Journal:  Molecules       Date:  2022-08-26       Impact factor: 4.927

2.  Immune Escape Adaptive Mutations in Hemagglutinin Are Responsible for the Antigenic Drift of Eurasian Avian-Like H1N1 Swine Influenza Viruses.

Authors:  Chengzhi Xu; Naixin Zhang; Yuying Yang; Wenhua Liang; Yaping Zhang; Jingfei Wang; Yasuo Suzuki; Yunpu Wu; Yan Chen; Huanliang Yang; Chuanling Qiao; Hualan Chen
Journal:  J Virol       Date:  2022-08-02       Impact factor: 6.549

  2 in total

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