BACKGROUND AND AIMS: The free radical theory of aging has been receiving a lot of attention in the past years. The aim of this study was to examine the correlation between oxidative damage, antioxidant enzyme activities and plasma antioxidant potential with clinical parameters in elderly people. METHODS: Elderly subjects over 80 years old were included in the study. Clinical data were collected based on the Cumulative Illness Rating Scale (n = 132). In addition, blood samples were collected to determine biochemical and oxidative stress. RESULTS: The results showed that the mean age of the participants was 85.1 ± 4.0 years old. Diabetic patients presented higher plasma protein carbonyl levels when compared with non-diabetic, and plasma levels of thiobarbituric acid-reactive substances were correlated to serum triglyceride and LDL fraction. In contrast, a lower plasma total antioxidant capacity presented a relation with the presence of diabetes and arterial hypertension. In addition, healthy elderly subjects presented a higher plasma total antioxidant capacity. CONCLUSION: Thus, it seemed that plasma antioxidant potential is a better predictor of successful aging in the elderly than oxidative damage parameters or plasma antioxidant enzyme activities.
BACKGROUND AND AIMS: The free radical theory of aging has been receiving a lot of attention in the past years. The aim of this study was to examine the correlation between oxidative damage, antioxidant enzyme activities and plasma antioxidant potential with clinical parameters in elderly people. METHODS: Elderly subjects over 80 years old were included in the study. Clinical data were collected based on the Cumulative Illness Rating Scale (n = 132). In addition, blood samples were collected to determine biochemical and oxidative stress. RESULTS: The results showed that the mean age of the participants was 85.1 ± 4.0 years old. Diabeticpatients presented higher plasma protein carbonyl levels when compared with non-diabetic, and plasma levels of thiobarbituric acid-reactive substances were correlated to serum triglyceride and LDL fraction. In contrast, a lower plasma total antioxidant capacity presented a relation with the presence of diabetes and arterial hypertension. In addition, healthy elderly subjects presented a higher plasma total antioxidant capacity. CONCLUSION: Thus, it seemed that plasma antioxidant potential is a better predictor of successful aging in the elderly than oxidative damage parameters or plasma antioxidant enzyme activities.
Authors: Kathy K Griendling; Rhian M Touyz; Jay L Zweier; Sergey Dikalov; William Chilian; Yeong-Renn Chen; David G Harrison; Aruni Bhatnagar Journal: Circ Res Date: 2016-07-14 Impact factor: 17.367
Authors: André M Jacomini; Danielle da Silva Dias; Janaina de Oliveira Brito; Roberta F da Silva; Henrique L Monteiro; Susana Llesuy; Kátia De Angelis; Sandra L Amaral; Anderson S Zago Journal: Front Physiol Date: 2017-03-07 Impact factor: 4.566
Authors: María J Roig-Revert; Antonio Lleó-Pérez; Vicente Zanón-Moreno; Bárbara Vivar-Llopis; Juan Marín-Montiel; Rosa Dolz-Marco; Luis Alonso-Muñoz; Mara Albert-Fort; María I López-Gálvez; David Galarreta-Mira; María F García-Esparza; Carmen Galbis-Estrada; Carla Marco-Ramirez; Kian Shoaie-Nia; Silvia M Sanz-González; Vicente Vila-Bou; Elena Bendala-Tufanisco; José J García-Medina; Carlo Nucci; Roberto Gallego-Pinazo; J Fernando Arévalo; Maria D Pinazo-Durán Journal: Biomed Res Int Date: 2015-11-04 Impact factor: 3.411