| Literature DB >> 24296945 |
N Martínez1, C Almaraz1, J P Vaqué1, I Varela2, S Derdak3, S Beltran3, M Mollejo4, Y Campos-Martin4, L Agueda3, A Rinaldi5, I Kwee6, M Gut3, J Blanc3, D Oscier7, J C Strefford8, J Martinez-Lopez9, A Salar10, F Sole11, J L Rodriguez-Peralto12, C Diez-Tascón13, J F García14, M Fraga15, E Sebastián16, J Alvés17, J Menárguez18, J González-Carreró19, L F Casado4, M Bayes3, F Bertoni20, I Gut3, M A Piris21.
Abstract
Splenic marginal zone lymphoma (SMZL) is a B-cell neoplasm whose molecular pathogenesis remains fundamentally unexplained, requiring more precise diagnostic markers. Previous molecular studies have revealed 7q loss and mutations of nuclear factor κB (NF-κB), B-cell receptor (BCR) and Notch signalling genes. We performed whole-exome sequencing in a series of SMZL cases. Results confirmed that SMZL is an entity distinct from other low-grade B-cell lymphomas, and identified mutations in multiple genes involved in marginal zone development, and others involved in NF-κB, BCR, chromatin remodelling and the cytoskeleton.Entities:
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Year: 2013 PMID： 24296945 DOI： 10.1038/leu.2013.365
Source DB: PubMed Journal: Leukemia ISSN： 0887-6924 Impact factor: 11.528