Nasser M Al-Daghri1, Omar S Al-Attas2, Majed Alokail2, Khalid Alkharfy3, Kaiser Wani1, Osama E Amer1, Saim Ul Haq1, Shakilur Rahman1, Abdullah M Alnaami1, Sarantis Livadas4, Anastasios Kollias4, Paris Charalampidis5, Shaun Sabico1. 1. 1] Biochemistry Department, Biomarkers Research Program, College of Science, King Saud University, Riyadh, Saudi Arabia [2] Biochemistry Department, Prince Mutaib Chair for Biomarkers of Osteoporosis, College of Science, King Saud University, Riyadh, Saudi Arabia. 2. 1] Biochemistry Department, Biomarkers Research Program, College of Science, King Saud University, Riyadh, Saudi Arabia [2] Biochemistry Department, Prince Mutaib Chair for Biomarkers of Osteoporosis, College of Science, King Saud University, Riyadh, Saudi Arabia [3] Center of Excellence in Biotechnology Research, King Saud University, Riyadh, Saudi Arabia. 3. 1] Biochemistry Department, Biomarkers Research Program, College of Science, King Saud University, Riyadh, Saudi Arabia [2] Biochemistry Department, Prince Mutaib Chair for Biomarkers of Osteoporosis, College of Science, King Saud University, Riyadh, Saudi Arabia [3] Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. 4. 3rd University Department of Internal Medicine, Sotiria Hospital, Athens, Greece. 5. First Department of Pediatrics, University of Athens School of Medicine, Athens, Greece.
Abstract
BACKGROUND: Visceral adiposity index (VAI) is a novel gender-specific index based on waist circumference (WC), BMI, and lipid parameters. Although VAI does not actually estimate visceral adiposity, it accurately reflects visceral fat function and insulin resistance. This index has not been studied in children thus far. This study aims to fill this gap. METHODS: In a cohort of Saudi children and adolescents, anthropometric measurements and metabolic/hormonal profile were obtained. RESULTS: A total of 543 subjects, 292 of whom were boys, were included (mean age: 11.9 ± 3.3 y; BMI: 19.8 ± 5.6 kg/m(2)). In all subjects, VAI was inferior to BMI and WC regarding its correlations with adiponectin, leptin, insulin resistance (homeostasis model of assessment-insulin resistance (HOMA-IR)), C-reactive protein (CRP) level, and systolic blood pressure, but it exhibited a stronger association with glucose in boys (r = 0.23; P < 0.01). In stepwise multivariate analyses, only BMI was consistent as an independent predictor of adiponectin, leptin, HOMA-IR, and CRP. VAI was the only index independently associated with glucose. CONCLUSION: Although VAI is related to glucose in children, it seems to be inferior to BMI in terms of association with insulin resistance, adipokines, and subclinical inflammation. Until specific studies can be performed in children, VAI should be extrapolated with caution in this age range.
BACKGROUND: Visceral adiposity index (VAI) is a novel gender-specific index based on waist circumference (WC), BMI, and lipid parameters. Although VAI does not actually estimate visceral adiposity, it accurately reflects visceral fat function and insulin resistance. This index has not been studied in children thus far. This study aims to fill this gap. METHODS: In a cohort of Saudi children and adolescents, anthropometric measurements and metabolic/hormonal profile were obtained. RESULTS: A total of 543 subjects, 292 of whom were boys, were included (mean age: 11.9 ± 3.3 y; BMI: 19.8 ± 5.6 kg/m(2)). In all subjects, VAI was inferior to BMI and WC regarding its correlations with adiponectin, leptin, insulin resistance (homeostasis model of assessment-insulin resistance (HOMA-IR)), C-reactive protein (CRP) level, and systolic blood pressure, but it exhibited a stronger association with glucose in boys (r = 0.23; P < 0.01). In stepwise multivariate analyses, only BMI was consistent as an independent predictor of adiponectin, leptin, HOMA-IR, and CRP. VAI was the only index independently associated with glucose. CONCLUSION: Although VAI is related to glucose in children, it seems to be inferior to BMI in terms of association with insulin resistance, adipokines, and subclinical inflammation. Until specific studies can be performed in children, VAI should be extrapolated with caution in this age range.
Authors: Lorena del Rocío Ibarra-Reynoso; Liudmila Pisarchyk; Elva Leticia Pérez-Luque; Ma Eugenia Garay-Sevilla; Juan Manuel Malacara Journal: PLoS One Date: 2014-11-20 Impact factor: 3.240
Authors: Susana Borruel; José F Moltó; Macarena Alpañés; Elena Fernández-Durán; Francisco Álvarez-Blasco; Manuel Luque-Ramírez; Héctor F Escobar-Morreale Journal: PLoS One Date: 2014-12-05 Impact factor: 3.240