Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Life without the mitochondrial calcium uniporter.

Literature DB >> 24296416

Life without the mitochondrial calcium uniporter.

Sébastien Herzig¹, Kinsey Maundrell, Jean-Claude Martinou.

Abstract

Calcium enters mitochondria through a dedicated channel referred to as the mitochondrial calcium uniporter (MCU), whose molecular identity has long remained elusive. Since the discovery of the gene encoding the MCU protein two years ago, researchers have awaited the generation of a mouse lacking the MCU. These mice are fully viable and show defects limited to performance of high-energy-demanding exercises. Strikingly, no protection against necrosis is observed following ischaemia-reperfusion in the heart.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 24296416 DOI： 10.1038/ncb2891

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

12 in total

Review 1. Mitochondrial transport of cations: channels, exchangers, and permeability transition.

Authors: P Bernardi
Journal: Physiol Rev Date: 1999-10 Impact factor: 37.312

2. Sarcoplasmic reticulum-mitochondrial interaction in the mechanism of acute reperfusion injury. Viewpoint.

Authors: Hans Michael Piper; Yaser Abdallah; Sascha Kasseckert; Klaus-Dieter Schlüter
Journal: Cardiovasc Res Date: 2007-11-11 Impact factor: 10.787

Review 3. Regulation of mitochondrial dehydrogenases by calcium ions.

Authors: Richard M Denton
Journal: Biochim Biophys Acta Date: 2009-01-20

4. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

Authors: Joshua M Baughman; Fabiana Perocchi; Hany S Girgis; Molly Plovanich; Casey A Belcher-Timme; Yasemin Sancak; X Robert Bao; Laura Strittmatter; Olga Goldberger; Roman L Bogorad; Victor Koteliansky; Vamsi K Mootha
Journal: Nature Date: 2011-06-19 Impact factor: 49.962

Review 5. Role of calcium ions in regulation of mammalian intramitochondrial metabolism.

Authors: J G McCormack; A P Halestrap; R M Denton
Journal: Physiol Rev Date: 1990-04 Impact factor: 37.312

Review 6. The mitochondrial permeability transition pore and its role in cell death.

Authors: M Crompton
Journal: Biochem J Date: 1999-07-15 Impact factor: 3.857

7. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.

Authors: Diego De Stefani; Anna Raffaello; Enrico Teardo; Ildikò Szabò; Rosario Rizzuto
Journal: Nature Date: 2011-06-19 Impact factor: 49.962

Review 8. The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles.

Authors: Maria Patron; Anna Raffaello; Veronica Granatiero; Anna Tosatto; Giulia Merli; Diego De Stefani; Lauren Wright; Giorgia Pallafacchina; Anna Terrin; Cristina Mammucari; Rosario Rizzuto
Journal: J Biol Chem Date: 2013-02-11 Impact factor: 5.157

9. Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals.

Authors: Jing Qiu; Yan-Wei Tan; Anna M Hagenston; Marc-Andre Martel; Niclas Kneisel; Paul A Skehel; David J A Wyllie; Hilmar Bading; Giles E Hardingham
Journal: Nat Commun Date: 2013 Impact factor: 14.919

10. The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.

Authors: Xin Pan; Jie Liu; Tiffany Nguyen; Chengyu Liu; Junhui Sun; Yanjie Teng; Maria M Fergusson; Ilsa I Rovira; Michele Allen; Danielle A Springer; Angel M Aponte; Marjan Gucek; Robert S Balaban; Elizabeth Murphy; Toren Finkel
Journal: Nat Cell Biol Date: 2013-11-10 Impact factor: 28.824

11 in total

Review 1. Molecular mechanism of mitochondrial calcium uptake.

Authors: Lele Wang; Xue Yang; Yuequan Shen
Journal: Cell Mol Life Sci Date: 2014-12-30 Impact factor: 9.261

Review 2. Mitochondria and carbon monoxide: cytoprotection and control of cell metabolism - a role for Ca(2+) ?

Authors: Sara R Oliveira; Cláudia S F Queiroga; Helena L A Vieira
Journal: J Physiol Date: 2015-12-07 Impact factor: 5.182

Review 3. Modulation of the matrix redox signaling by mitochondrial Ca(2.).

Authors: Jaime Santo-Domingo; Andreas Wiederkehr; Umberto De Marchi
Journal: World J Biol Chem Date: 2015-11-26

Review 4. Crosslink between calcium and sodium signalling.

Authors: Alexei Verkhratsky; Mohamed Trebak; Fabiana Perocchi; Daniel Khananshvili; Israel Sekler
Journal: Exp Physiol Date: 2018-01-16 Impact factor: 2.969

Review 5. The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways.

Authors: Bong Sook Jhun; Jyotsna Mishra; Sarah Monaco; Deming Fu; Wenmin Jiang; Shey-Shing Sheu; Jin O-Uchi
Journal: Am J Physiol Cell Physiol Date: 2016-04-27 Impact factor: 4.249

6. Calcium movement in cardiac mitochondria.

Authors: Liron Boyman; Aristide C Chikando; George S B Williams; Ramzi J Khairallah; Sarah Kettlewell; Christopher W Ward; Godfrey L Smith; Joseph P Y Kao; W Jonathan Lederer
Journal: Biophys J Date: 2014-09-16 Impact factor: 4.033

Review 7. Mitochondria as key targets of cardioprotection in cardiac ischemic disease: role of thyroid hormone triiodothyronine.

Authors: Francesca Forini; Giuseppina Nicolini; Giorgio Iervasi
Journal: Int J Mol Sci Date: 2015-03-19 Impact factor: 5.923

Life without the mitochondrial calcium uniporter.

Review 1. Mitochondrial transport of cations: channels, exchangers, and permeability transition.

2. Sarcoplasmic reticulum-mitochondrial interaction in the mechanism of acute reperfusion injury. Viewpoint.

Review 3. Regulation of mitochondrial dehydrogenases by calcium ions.

4. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

Review 5. Role of calcium ions in regulation of mammalian intramitochondrial metabolism.

Review 6. The mitochondrial permeability transition pore and its role in cell death.

7. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.

Review 8. The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles.

9. Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals.

10. The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.

Review 1. Molecular mechanism of mitochondrial calcium uptake.

Review 2. Mitochondria and carbon monoxide: cytoprotection and control of cell metabolism - a role for Ca(2+) ?

Review 3. Modulation of the matrix redox signaling by mitochondrial Ca(2.).

Review 4. Crosslink between calcium and sodium signalling.

Review 5. The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways.

6. Calcium movement in cardiac mitochondria.

Review 7. Mitochondria as key targets of cardioprotection in cardiac ischemic disease: role of thyroid hormone triiodothyronine.

Review 8. Neurointegrity and neurophysiology: astrocyte, glutamate, and carbon monoxide interactions.

Review 9. Role of mitochondrial Ca²⁺ homeostasis in cardiac muscles.

Review 10. Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans.

Life without the mitochondrial calcium uniporter.

Review 1. Mitochondrial transport of cations: channels, exchangers, and permeability transition.

2. Sarcoplasmic reticulum-mitochondrial interaction in the mechanism of acute reperfusion injury. Viewpoint.

Review 3. Regulation of mitochondrial dehydrogenases by calcium ions.

4. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

Review 5. Role of calcium ions in regulation of mammalian intramitochondrial metabolism.

Review 6. The mitochondrial permeability transition pore and its role in cell death.

7. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.

Review 8. The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles.

9. Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals.

10. The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.

Review 1. Molecular mechanism of mitochondrial calcium uptake.

Review 2. Mitochondria and carbon monoxide: cytoprotection and control of cell metabolism - a role for Ca(2+) ?

Review 3. Modulation of the matrix redox signaling by mitochondrial Ca(2.).

Review 4. Crosslink between calcium and sodium signalling.

Review 5. The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways.

6. Calcium movement in cardiac mitochondria.

Review 7. Mitochondria as key targets of cardioprotection in cardiac ischemic disease: role of thyroid hormone triiodothyronine.

Review 8. Neurointegrity and neurophysiology: astrocyte, glutamate, and carbon monoxide interactions.

Review 9. Role of mitochondrial Ca2+ homeostasis in cardiac muscles.

Review 10. Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans.

Review 9. Role of mitochondrial Ca²⁺ homeostasis in cardiac muscles.