| Literature DB >> 24296406 |
Jianteng Wei1, Shuxian Wang2, Ge Liu3, Dong Pei1, Yongfeng Liu1, Yi Liu1, Duolong Di4.
Abstract
The effects of polysaccharides from Enteromorpha prolifera (PEP) on cell-mediated immunity, humoral immunity and mononuclear phagocytic system function were evaluated to assess the immunomodulatory potential of these macromolecules. Relevant immunological mechanisms were verified by biochemical assays and western blot analysis. Results showed that PEP could induce splenocyte proliferation. In vivo experiments on Kunming mice confirmed that PEP could improve cell-mediated immunity, humoral immunity and mononuclear phagocytic system function. To illustrate the mechanism, we determined several immune-related enzymes in the thymus and spleen. The results indicated that PEP could enhance the activities of alkaline phosphatase, superoxide dismutase and lactate dehydrogenase. PEP could also increase the level of NF-κB. These results suggested that PEP exhibited potent immunomodulatory properties and could be used as a novel potential immunostimulant in food and pharmaceutical industries.Entities:
Keywords: Enteromorpha prolifera; Immune response; Immune-related enzyme; NF-κB; Polysaccharide
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Year: 2013 PMID： 24296406 DOI： 10.1016/j.ijbiomac.2013.11.013
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953