Xiaoyu Liu1, Ling Liu1, Pinyi Chen1, Liang Zhou1, Yanqi Zhang1, Yazhou Wu1, Lei Jiang2, Dixiang Cheng3, Wenquan Huang2, Dong Yi4. 1. Department of Health Statistics, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China. 2. Department of Rehabilitation and Physiotherapy, Xinqiao Hospital, Third Military Medical University, Chongqing 400038, China. 3. Soft College, Chongqing University of Posts and Telecommunications, Chongqing 400065, China. 4. Department of Health Statistics, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China. Electronic address: liuxy1105@163.com.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: The purpose of this study is to systematically evaluate the efficacy of traditional Chinese medicine (TCM) decoctions with different ingredients in the treatment of diabetic nephropathy (DN). MATERIALS AND METHODS: Papers obtained after the retrieval of randomized controlled clinical trials (RCTs) of TCM treatments of diabetic nephropathy through online database (e.g. Medline, CBM, CNKI, VIP, the online database of Chinese medicine, CDFD, CMFD, and CENTRAL FROM Cochrane Library, etc.) as well as research data in our library. They were published between January 2001 and December 2012. According to the categories of the main TCM ingredients, all the cases in the literature were divided into a liver-kidney YIN deficiency group, a QI-BLOOD YIN-and-YANG deficiency group, and a spleen-kidney YANG deficiency group. Stata 11.0 was applied for subgroup analysis. RESULTS: A total of 21 Chinese RCTs were included in this review. The Q values of the three groups were 13.18, 0.25 and 3.27, respectively, P>0.05, and thus, there was no clinical heterogeneity. The combined relative risk (RR) value and its 95% confidence interval were 1.48 (1.37, 1.60), 1.19 (1.06, 1.34), and 1.33 (1.19, 1.50), respectively, P<0.05. CONCLUSIONS: Compared with the qi-blood yin-and-yang deficiency group and the spleen-kidney yang deficiency group, the liver-kidney yin deficiency group has better prospects in clinical application to ensure renal function during the treatment of DN, and this possibility is worthy of further study.
ETHNOPHARMACOLOGICAL RELEVANCE: The purpose of this study is to systematically evaluate the efficacy of traditional Chinese medicine (TCM) decoctions with different ingredients in the treatment of diabetic nephropathy (DN). MATERIALS AND METHODS: Papers obtained after the retrieval of randomized controlled clinical trials (RCTs) of TCM treatments of diabetic nephropathy through online database (e.g. Medline, CBM, CNKI, VIP, the online database of Chinese medicine, CDFD, CMFD, and CENTRAL FROM Cochrane Library, etc.) as well as research data in our library. They were published between January 2001 and December 2012. According to the categories of the main TCM ingredients, all the cases in the literature were divided into a liver-kidney YIN deficiency group, a QI-BLOOD YIN-and-YANG deficiency group, and a spleen-kidney YANG deficiency group. Stata 11.0 was applied for subgroup analysis. RESULTS: A total of 21 Chinese RCTs were included in this review. The Q values of the three groups were 13.18, 0.25 and 3.27, respectively, P>0.05, and thus, there was no clinical heterogeneity. The combined relative risk (RR) value and its 95% confidence interval were 1.48 (1.37, 1.60), 1.19 (1.06, 1.34), and 1.33 (1.19, 1.50), respectively, P<0.05. CONCLUSIONS: Compared with the qi-blood yin-and-yang deficiency group and the spleen-kidney yang deficiency group, the liver-kidney yin deficiency group has better prospects in clinical application to ensure renal function during the treatment of DN, and this possibility is worthy of further study.
Keywords:
CBM; CDMD; CNKI; Chinese academy of sciences database; Chinese biomedical literature database; Chinese doctoral dissertation full-text database; DN; Diabetic nephropathy; RCT; Subgroup meta-analysis; Systematic review; TCM; Traditional Chinese medicine; diabetic nephropathy; randomized controlled clinical trial; traditional Chinese medicine