Roland N Dickerson1, Allison M Lynch2, George O Maish3, Martin A Croce3, Gayle Minard3, Rex O Brown4. 1. Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address: Rdickerson@uthsc.edu. 2. Department of Pharmacy, Duke University Hospital, Durham, NC, USA. 3. Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA. 4. Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.
Abstract
OBJECTIVE: The aim of this study was to evaluate the safety and efficacy of a new intravenous (IV) regular human insulin infusion (RHI) algorithm for glycemic control in critically ill patients with renal failure. METHODS: Adult trauma patients with renal failure who received a new RHI algorithm were compared with those who received the discontinued RHI algorithm (historical control). Target blood glucose (BG) concentration was 70 to 149 mg/dL (3.9-8.3 mmol/L). Patients were evaluated for 7 d while receiving the RHI infusion and continuous enteral or parenteral nutrition. RESULTS: Mean BG was higher for the new RHI algorithm group (n = 25) compared with control (n = 21): 145 ± 10 mg/dL or 8.1 ± 0.6 mmol/L versus 133 ± 14 mg/dL or 7.4 ± 0.8 mmol/L (P = 0.001). The new RHI algorithm resulted in less time within the target BG range (11.9 ± 2.5 h/d versus 16.1 ± 3.3 h/d; P = 0.001); however, BGs were within 70 to 179 mg/dL (or 3.9-10 mmol/L) for 16.3 ± 2.6 h/d. The proportion of patients who experienced an episode of moderate hypoglycemia (BG 40-60 mg/dL or 2.2-3.3 mmol/L) or severe hypoglycemia (BG < 40 mg/dL or 2.2 mmol/L) was decreased (32% versus 76%; P = 0.001) and eliminated (0% versus 29%, P = 0.006), respectively. CONCLUSIONS: The new RHI algorithm improved patient safety by decreasing the prevalence of moderate hypoglycemia and eliminating severe hypoglycemia. The duration of glycemic control within the target BG range was decreased, but acceptable within a higher target BG ceiling.
OBJECTIVE: The aim of this study was to evaluate the safety and efficacy of a new intravenous (IV) regular humaninsulin infusion (RHI) algorithm for glycemic control in critically illpatients with renal failure. METHODS: Adult traumapatients with renal failure who received a new RHI algorithm were compared with those who received the discontinued RHI algorithm (historical control). Target blood glucose (BG) concentration was 70 to 149 mg/dL (3.9-8.3 mmol/L). Patients were evaluated for 7 d while receiving the RHI infusion and continuous enteral or parenteral nutrition. RESULTS: Mean BG was higher for the new RHI algorithm group (n = 25) compared with control (n = 21): 145 ± 10 mg/dL or 8.1 ± 0.6 mmol/L versus 133 ± 14 mg/dL or 7.4 ± 0.8 mmol/L (P = 0.001). The new RHI algorithm resulted in less time within the target BG range (11.9 ± 2.5 h/d versus 16.1 ± 3.3 h/d; P = 0.001); however, BGs were within 70 to 179 mg/dL (or 3.9-10 mmol/L) for 16.3 ± 2.6 h/d. The proportion of patients who experienced an episode of moderate hypoglycemia (BG 40-60 mg/dL or 2.2-3.3 mmol/L) or severe hypoglycemia (BG < 40 mg/dL or 2.2 mmol/L) was decreased (32% versus 76%; P = 0.001) and eliminated (0% versus 29%, P = 0.006), respectively. CONCLUSIONS: The new RHI algorithm improved patient safety by decreasing the prevalence of moderate hypoglycemia and eliminating severe hypoglycemia. The duration of glycemic control within the target BG range was decreased, but acceptable within a higher target BG ceiling.
Authors: Roland N Dickerson; Vanessa J Kumpf; Allison B Blackmer; Angela L Bingham; Anne M Tucker; Joseph V Ybarra; Michael D Kraft; Todd W Canada Journal: Hosp Pharm Date: 2016-07
Authors: Roland N Dickerson; Jonathan R Van Cleve; Joseph M Swanson; George O Maish; Gayle Minard; Martin A Croce; Rex O Brown Journal: Burns Trauma Date: 2016-10-17