Lechun Lu1, Wenjuan Wu2, Ying Tu2, Zhi Yang2, Li He3, Meihua Guo4. 1. Department of Physiology, School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan, China. 2. Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. 3. Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. Electronic address: heli2661@163.com. 4. Division of Science and Technology, Kunming Medical University, Kunming, Yunnan, China. Electronic address: glassgreen@163.com.
Abstract
BACKGROUND: Some studies suggested that Glutathione S-transferases M1/T1(GSTM1/T1) null polymorphisms may be associated with the risk of vitiligo. AIMS: The purpose of this study is to further evaluate the association between GSTM1/T1 null polymorphisms and the susceptibility to vitiligo. METHODS: We carried out a retrieval of studies in the databases. Odds ratios (OR) and 95% confidence intervals (95% CIs) were used to assess the strength of this association. We analyzed the data using Stata 11.0. RESULTS: Six case-control studies including 1358 cases and 1673 controls were included in this meta-analysis. Our overall results showed the GSTM1 or GSTT1 null polymorphism was associated with vitiligo (GSTM1:OR=1.59, 95% CI: 1.21-2.08, P=0.001; GSTT1: OR=1.30, 95% CI: 1.12-1.51, P=0.001). In the subgroup analysis, the GSTM1 null polymorphism might be a genetic risk factor to vitiligo in East Asian (OR=1.71, 95% CI: 1.12-2.63, P=0.014) but not in the Mediterranean, however individuals with the GSTT1 null polymorphism in the Mediterranean (OR=1.76, 95% CI: 1.15-2.71, P=0.010) but not in East Asian have a greater predisposition to vitiligo. In addition there was also a significant trend toward an association with the combination of the GSTM1 null and GSTT1 null in either East Asians or Mediterraneans. CONCLUSION: The GSTM1/T1 null polymorphisms may be associated with vitiligo. More studies are needed to confirm this conclusion.
BACKGROUND: Some studies suggested that Glutathione S-transferases M1/T1(GSTM1/T1) null polymorphisms may be associated with the risk of vitiligo. AIMS: The purpose of this study is to further evaluate the association between GSTM1/T1 null polymorphisms and the susceptibility to vitiligo. METHODS: We carried out a retrieval of studies in the databases. Odds ratios (OR) and 95% confidence intervals (95% CIs) were used to assess the strength of this association. We analyzed the data using Stata 11.0. RESULTS: Six case-control studies including 1358 cases and 1673 controls were included in this meta-analysis. Our overall results showed the GSTM1 or GSTT1 null polymorphism was associated with vitiligo (GSTM1:OR=1.59, 95% CI: 1.21-2.08, P=0.001; GSTT1: OR=1.30, 95% CI: 1.12-1.51, P=0.001). In the subgroup analysis, the GSTM1 null polymorphism might be a genetic risk factor to vitiligo in East Asian (OR=1.71, 95% CI: 1.12-2.63, P=0.014) but not in the Mediterranean, however individuals with the GSTT1 null polymorphism in the Mediterranean (OR=1.76, 95% CI: 1.15-2.71, P=0.010) but not in East Asian have a greater predisposition to vitiligo. In addition there was also a significant trend toward an association with the combination of the GSTM1 null and GSTT1 null in either East Asians or Mediterraneans. CONCLUSION: The GSTM1/T1 null polymorphisms may be associated with vitiligo. More studies are needed to confirm this conclusion.