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Literature DB >> 24294824

Multilayered polymer-coated carbon nanotubes to deliver dasatinib.

Thomas L Moore¹, Stuart W Grimes, Robert L Lewis, Frank Alexis.

Abstract

Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 24294824 PMCID： PMC4065492 DOI： 10.1021/mp400448w

Source DB: PubMed Journal: Mol Pharm ISSN： 1543-8384 Impact factor: 4.939

31 in total

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Authors: Louis J Lombardo; Francis Y Lee; Ping Chen; Derek Norris; Joel C Barrish; Kamelia Behnia; Stephen Castaneda; Lyndon A M Cornelius; Jagabandhu Das; Arthur M Doweyko; Craig Fairchild; John T Hunt; Ivan Inigo; Kathy Johnston; Amrita Kamath; David Kan; Herbert Klei; Punit Marathe; Suhong Pang; Russell Peterson; Sidney Pitt; Gary L Schieven; Robert J Schmidt; John Tokarski; Mei-Li Wen; John Wityak; Robert M Borzilleri
Journal: J Med Chem Date: 2004-12-30 Impact factor: 7.446

2. Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window.

Authors: Kevin Welsher; Sarah P Sherlock; Hongjie Dai
Journal: Proc Natl Acad Sci U S A Date: 2011-05-16 Impact factor: 11.205

3. Designing multilayered particulate systems for tunable drug release profiles.

Authors: Wei Li Lee; Pattara-orn Yu; Meiju Hong; Effendi Widjaja; Say Chye Joachim Loo
Journal: Acta Biomater Date: 2012-02-13 Impact factor: 8.947

4. Altering the drug release profiles of double-layered ternary-phase microparticles.

Authors: Wei Li Lee; Cedric Loei; Effendi Widjaja; Say Chye Joachim Loo
Journal: J Control Release Date: 2011-02-23 Impact factor: 9.776

5. Small-molecule release from poly(D,L-lactide)/poly(D,L-lactide-co-glycolide) composite microparticles.

Authors: Emily J Pollauf; Kyekyoon Kevin Kim; Daniel W Pack
Journal: J Pharm Sci Date: 2005-09 Impact factor: 3.534

6. Incorporation and controlled release of silyl ether prodrugs from PRINT nanoparticles.

Authors: Matthew C Parrott; Mathew Finniss; J Chris Luft; Ashish Pandya; Anuradha Gullapalli; Mary E Napier; Joseph M DeSimone
Journal: J Am Chem Soc Date: 2012-04-30 Impact factor: 15.419

7. Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile.

Authors: Jeffrey Hrkach; Daniel Von Hoff; Mir Mukkaram Ali; Elizaveta Andrianova; Jason Auer; Tarikh Campbell; David De Witt; Michael Figa; Maria Figueiredo; Allen Horhota; Susan Low; Kevin McDonnell; Erick Peeke; Beadle Retnarajan; Abhimanyu Sabnis; Edward Schnipper; Jeffrey J Song; Young Ho Song; Jason Summa; Douglas Tompsett; Greg Troiano; Tina Van Geen Hoven; Jim Wright; Patricia LoRusso; Philip W Kantoff; Neil H Bander; Christopher Sweeney; Omid C Farokhzad; Robert Langer; Stephen Zale
Journal: Sci Transl Med Date: 2012-04-04 Impact factor: 17.956

8. Tissue histology and physiology following intravenous administration of different types of functionalized multiwalled carbon nanotubes.

Authors: Lara Lacerda; Hanene Ali-Boucetta; Maria A Herrero; Giorgia Pastorin; Alberto Bianco; Maurizio Prato; Kostas Kostarelos
Journal: Nanomedicine (Lond) Date: 2008-04 Impact factor: 5.307

9. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study.

Authors: Craig A Poland; Rodger Duffin; Ian Kinloch; Andrew Maynard; William A H Wallace; Anthony Seaton; Vicki Stone; Simon Brown; William Macnee; Ken Donaldson
Journal: Nat Nanotechnol Date: 2008-05-20 Impact factor: 39.213

10. Fluorine-labeled dasatinib nanoformulations as targeted molecular imaging probes in a PDGFB-driven murine glioblastoma model.

Authors: Miriam Benezra; Dolores Hambardzumyan; Oula Penate-Medina; Darren R Veach; Nagavarakishore Pillarsetty; Peter Smith-Jones; Evan Phillips; Tatsuya Ozawa; Pat B Zanzonico; Valerie Longo; Eric C Holland; Steven M Larson; Michelle S Bradbury
Journal: Neoplasia Date: 2012-12 Impact factor: 5.715

7 in total

1. Development and Characterization of the Paclitaxel loaded Riboflavin and Thiamine Conjugated Carbon Nanotubes for Cancer Treatment.

Authors: Swati Singh; Neelesh Kumar Mehra; N K Jain
Journal: Pharm Res Date: 2016-04-18 Impact factor: 4.200

Review 2. Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses.

Authors: Panoraia I Siafaka; Neslihan Üstündağ Okur; Evangelos Karavas; Dimitrios N Bikiaris
Journal: Int J Mol Sci Date: 2016-08-31 Impact factor: 5.923

Review 3. Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma.

Authors: Amy Lee Bredlau; Suraj Dixit; Chao Chen; Ann-Marie Broome
Journal: Curr Neuropharmacol Date: 2017 Impact factor: 7.363

4. Poly(Cyclohexene Phthalate) Nanoparticles for Controlled Dasatinib Delivery in Breast Cancer Therapy.

Authors: Enrique Niza; Cristina Nieto-Jiménez; María Del Mar Noblejas-López; Iván Bravo; José Antonio Castro-Osma; Felipe de la Cruz-Martínez; Marc Martínez de Sarasa Buchaca; Inmaculada Posadas; Jesús Canales-Vázquez; Agustín Lara-Sanchez; Daniel Hermida-Merino; Eduardo Solano; Alberto Ocaña; Carlos Alonso-Moreno
Journal: Nanomaterials (Basel) Date: 2019-08-27 Impact factor: 5.076