In utero arterial thrombosis treated with recombinant tissue plasminogen activator in an infant of a diabetic mother: A case report and literature review.

A 36+5 days' gestation infant of a diabetic mother suffered arterial thrombosis with severe vascular occlusions in multiple limbs, especially of the left upper extremity. Although the mechanism remains elusive, the association between venous and arterial thrombi in infants and diabetic mothers has previously been established. Cases typically result in the amputation of the dysvascular limbs. In the present case, the use of selective angiography to administer recombinant tissue plasminogen activator allowed the left upper extremity to be salvaged with amputation of only the left thumb.