| Literature DB >> 24293253 |
Susana Junqueira-Neto1, Filipa Q Vieira1,2, Diana Montezuma1,3, Natália R Costa1, Luís Antunes4, Tiago Baptista1, Ana Isabel Oliveira1, Inês Graça1,2, Ângelo Rodrigues3, José S Magalhães5, Jorge Oliveira5, Rui Henrique1,3,6, Carmen Jerónimo1,6.
Abstract
Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.Entities:
Keywords: apoptosis; bladder cancer; class I HDACs; viability
Mesh：
Substances：
Year: 2013 PMID： 24293253 DOI： 10.1002/mc.22117
Source DB: PubMed Journal: Mol Carcinog ISSN： 0899-1987 Impact factor: 4.784